Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma.
PMID 28761441 | PMCID PMC5518512 | DOI 10.1155/2017/7150386 · Gastroenterology research and practice · 2017 · View on PubMed ↗
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related mortality worldwide. Host gene variants may influence hepatitis B virus- (HBV-) related HCC. Human leukocyte antigens (HLA) play an important role in presenting virus antigens to immune cells that are responsible for the clearance of virus-infected cells and tumor cells. Previous studies have investigated the HLA-DQ (rs2856718 and rs9275572) polymorphisms that may be associated with the development of HBV-related HCC. However, the results are controversial or inconclusive. Hence, we conducted a meta-analysis to derive a more precise estimation of the associations. A total of 6 articles were used to evaluate the effect of the two polymorphisms on the risk of HBV-related HCC. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. We found that rs2856718 and rs9275572 in HLA-DQ significantly decreased HBV-related HCC in total population, especially in Chinese, but not in Saudi Arabian. Further validation of our results in larger populations and different ethnicities are required.
Validated evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| phenotype | hepatocellular carcinoma | “Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | hepatitis B | “Host gene variants may influence hepatitis B virus- (HBV-) related HCC.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “We found that rs2856718 and rs9275572 in HLA-DQ significantly decreased HBV-related HCC in total population, especially in Chinese, but not in Saudi Arabian.” | 0.95 | saudi_context_rules_v1 |
| variant | rs2856718 | “Previous studies have investigated the HLA-DQ (rs2856718 and rs9275572) polymorphisms that may be associated with the development of HBV-related HCC.” | 0.90 | hgvs_regex_v1 |
| variant | rs9275572 | “Previous studies have investigated the HLA-DQ (rs2856718 and rs9275572) polymorphisms that may be associated with the development of HBV-related HCC.” | 0.90 | hgvs_regex_v1 |