Significant Association Between Genetic Polymorphism of Insulin-Like Growth Factor-2 mRNA Binding Protein-2 and Type 2 Diabetes Mellitus: A Population-Based Case-Control Study.
PMID 39749895 | PMCID PMC11821720 | DOI 10.1002/jcla.25147 · Journal of clinical laboratory analysis · 2025 · View on PubMed ↗
OBJECTIVES: To determine the association between IGF2BP2 polymorphisms and type 2 diabetes mellitus. METHODS: This study involved 422 individuals, 214 diabetes mellitus cases, and 208 healthy controls. The PCR-RFLP technique was used to determine the genotype of the IGF2BP2 gene for the SNPs rs4402960 (G>T) and rs1470579 (A>C). RESULTS: The results showed that the C allele of the rs1470579 variant and the T allele of the rs440960 variant were significantly associated with type 2 diabetes mellitus group (p = 0.0029 and 0.0001) as reported for both alleles, respectively. High frequencies of haplotypes TA and TC were observed in type 2 diabetes patients. CONCLUSION: The present study showed that IGF2BP2 rs1470579 and rs4402960 polymorphism were significantly associated with the increased risk of T2DM in the Saudi Arabian population and presented a genetic model to screen the high-risk individuals with further validations.
Validated evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | IGF2BP2 | “OBJECTIVES: To determine the association between IGF2BP2 polymorphisms and type 2 diabetes mellitus.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Significant Association Between Genetic Polymorphism of Insulin-Like Growth Factor-2 mRNA Binding Protein-2 and Type 2 Diabetes Mellitus: A Population-Based Case-Control Study.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “METHODS: This study involved 422 individuals, 214 diabetes mellitus cases, and 208 healthy controls. CONCLUSION: The present study showed that IGF2BP2 rs1470579 and rs4402960 polymorphism were significantly associated with the increased risk of T2DM in the Saudi Arabian population and presented a genetic model to screen the high-risk individuals with further validations.” | 0.95 | saudi_context_rules_v1 |
| variant | rs4402960 | “The PCR-RFLP technique was used to determine the genotype of the IGF2BP2 gene for the SNPs rs4402960 (G>T) and rs1470579 (A>C).” | 0.90 | hgvs_regex_v1 |
| variant | rs1470579 | “The PCR-RFLP technique was used to determine the genotype of the IGF2BP2 gene for the SNPs rs4402960 (G>T) and rs1470579 (A>C).” | 0.90 | hgvs_regex_v1 |
| variant | rs440960 | “RESULTS: The results showed that the C allele of the rs1470579 variant and the T allele of the rs440960 variant were significantly associated with type 2 diabetes mellitus group (p = 0.0029 and 0.0001) as reported for both alleles, respectively.” | 0.90 | hgvs_regex_v1 |