Association of Voltage-Gated Potassium Channel Polymorphisms with the Risk and Prognosis of Epilepsy in the Saudi Population: A Case-Control Study.
PMID 40142207 | PMCID PMC11943637 | DOI 10.3390/medicina61030396 · Medicina (Kaunas, Lithuania) · 2025 · View on PubMed ↗
Background and Objectives: Epilepsy, known as an unprovoked seizure, arises from the human brain. Genetics plays a fundamental role in the development and progression of the disorder. This study aimed to investigate the influence of voltage-gated K+ channels on the risk of epilepsy. Materials and Methods: Several genetic variants were examined using PCR sequencing. This case-control study was conducted on 296 individuals who were diagnosed with epilepsy, in addition to 293 healthy participants. Results: This study revealed that within KCNAB1, both rs3755631 and rs4679773 are correlated with epilepsy, and the p-values = 0.04 for both allelic associations. In addition, regarding the KCNJ10 gene, we found that rs2820585, rs946420, rs1186679, rs61822012, and rs1186685 were significantly correlated with epilepsy risk (p-values = 0.034, 0.045, 0.021, 0.048, and 0.018), respectively. Conclusions: From the current study, we conclude that voltage-gated potassium channels can impact epilepsy risk and can also interfere with the prognosis of epilepsy.
Validated evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | KCNAB1 | “Results: This study revealed that within KCNAB1, both rs3755631 and rs4679773 are correlated with epilepsy, and the p-values = 0.04 for both allelic associations.” | 0.98 | hgnc_dict_v1 |
| gene | KCNJ10 | “In addition, regarding the KCNJ10 gene, we found that rs2820585, rs946420, rs1186679, rs61822012, and rs1186685 were significantly correlated with epilepsy risk (p-values = 0.034, 0.045, 0.021, 0.048, and 0.018), respectively.” | 0.98 | hgnc_dict_v1 |
| phenotype | epilepsy | “Association of Voltage-Gated Potassium Channel Polymorphisms with the Risk and Prognosis of Epilepsy in the Saudi Population: A Case-Control Study.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Association of Voltage-Gated Potassium Channel Polymorphisms with the Risk and Prognosis of Epilepsy in the Saudi Population: A Case-Control Study. This case-control study was conducted on 296 individuals who were diagnosed with epilepsy, in addition to 293 healthy participants.” | 0.95 | saudi_context_rules_v1 |
| variant | rs3755631 | “Results: This study revealed that within KCNAB1, both rs3755631 and rs4679773 are correlated with epilepsy, and the p-values = 0.04 for both allelic associations.” | 0.90 | hgvs_regex_v1 |
| variant | rs4679773 | “Results: This study revealed that within KCNAB1, both rs3755631 and rs4679773 are correlated with epilepsy, and the p-values = 0.04 for both allelic associations.” | 0.90 | hgvs_regex_v1 |
| variant | rs2820585 | “In addition, regarding the KCNJ10 gene, we found that rs2820585, rs946420, rs1186679, rs61822012, and rs1186685 were significantly correlated with epilepsy risk (p-values = 0.034, 0.045, 0.021, 0.048, and 0.018), respectively.” | 0.90 | hgvs_regex_v1 |
| variant | rs946420 | “In addition, regarding the KCNJ10 gene, we found that rs2820585, rs946420, rs1186679, rs61822012, and rs1186685 were significantly correlated with epilepsy risk (p-values = 0.034, 0.045, 0.021, 0.048, and 0.018), respectively.” | 0.90 | hgvs_regex_v1 |
| variant | rs1186679 | “In addition, regarding the KCNJ10 gene, we found that rs2820585, rs946420, rs1186679, rs61822012, and rs1186685 were significantly correlated with epilepsy risk (p-values = 0.034, 0.045, 0.021, 0.048, and 0.018), respectively.” | 0.90 | hgvs_regex_v1 |
| variant | rs61822012 | “In addition, regarding the KCNJ10 gene, we found that rs2820585, rs946420, rs1186679, rs61822012, and rs1186685 were significantly correlated with epilepsy risk (p-values = 0.034, 0.045, 0.021, 0.048, and 0.018), respectively.” | 0.90 | hgvs_regex_v1 |
| variant | rs1186685 | “In addition, regarding the KCNJ10 gene, we found that rs2820585, rs946420, rs1186679, rs61822012, and rs1186685 were significantly correlated with epilepsy risk (p-values = 0.034, 0.045, 0.021, 0.048, and 0.018), respectively.” | 0.90 | hgvs_regex_v1 |