Prognostic Role of L1CAM in Endometrial Cancer.
PMID 40870967 | PMCID PMC12385864 | DOI 10.3390/diagnostics15162115 · Diagnostics (Basel, Switzerland) · 2025 · View on PubMed ↗
The L1 molecule is a cell adhesion molecule (L1CAM) that was originally implicated in neuronal development. In recent years, studies of several large cohorts of patients with endometrial cancer have revealed that L1CAM acts as a poor prognostic factor, in most cases independent of other parameters. It seems to be an important factor, especially in the non-specific molecular profile subgroup (p53 normal expression, MMR proficient, POLE not mutated) of endometrial cancer, and a factor predictive of the response to chemotherapy. This review aims to gather most of the current knowledge regarding this promising prognostic factor.
Validated evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | L1CAM | “Prognostic Role of L1CAM in Endometrial Cancer.” | 0.98 | hgnc_dict_v1 |
| gene | POLE | “It seems to be an important factor, especially in the non-specific molecular profile subgroup (p53 normal expression, MMR proficient, POLE not mutated) of endometrial cancer, and a factor predictive of the response to chemotherapy.” | 0.98 | hgnc_dict_v1 |
| phenotype | endometrial cancer | “Prognostic Role of L1CAM in Endometrial Cancer.” | 0.98 | phenotype_alias_lexicon_v2 |