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ABCG2 and breast cancer are reported together in 5 articles.
Gene
ABCG2
- HGNC
- HGNC:74
21articles
21mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 5HIV infection 2congenital myopathy 2dyslipidemia 2rheumatoid arthritis 2colorectal cancer 1ovarian cancer 1prostate cancer 1
Reported variants (articles · ClinVar status)
Phenotype
Breast cancer
1,211articles
1,211mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
5 records shown · first 60Association of ATP-binding cassette transporter genomic alterations and expressions with patient survival in breast and prostate cancer.
PMID 40641097 | PMCID PMC12245978 | DOI 10.14814/phy2.70460 · Physiological reports · 2025 · 12 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ABCG2 | “DepMap analysis revealed the overall dependency of cancer cell lines on ABC transporter genes such as ABCG2, ABCG1, ABCC4, ABCA2, ABCA3, ABCC2, ABCC3, ABCC6, ABCC7 (CFTR), and ABCC9, with ABCC6 and ABCC7 showing notably high dependence.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Data from the cBioPortal for Cancer Genomics, incorporating multiple phase-3 randomized clinical trials, identified genomic alterations including amplifications, deletions, and mutations in breast cancer patients (32 studies, 15,404 samples) and prostate cancer patients (29 studies, 13,857 samples).” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | ABCG1 | “DepMap analysis revealed the overall dependency of cancer cell lines on ABC transporter genes such as ABCG2, ABCG1, ABCC4, ABCA2, ABCA3, ABCC2, ABCC3, ABCC6, ABCC7 (CFTR), and ABCC9, with ABCC6 and ABCC7 showing notably high dependence.” | 0.98 | hgnc_dict_v1 |
| gene | ABCC4 | “DepMap analysis revealed the overall dependency of cancer cell lines on ABC transporter genes such as ABCG2, ABCG1, ABCC4, ABCA2, ABCA3, ABCC2, ABCC3, ABCC6, ABCC7 (CFTR), and ABCC9, with ABCC6 and ABCC7 showing notably high dependence.” | 0.98 | hgnc_dict_v1 |
In Silico Targeting Human Multidrug Transporter ABCG2 in Breast Cancer: Database Screening, Molecular Docking, and Molecular Dynamics Study.
PMID 34491628 | DOI 10.1002/minf.202060039 · Molecular informatics · 2022 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ABCG2 | “In Silico Targeting Human Multidrug Transporter ABCG2 in Breast Cancer: Database Screening, Molecular Docking, and Molecular Dynamics Study.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “In Silico Targeting Human Multidrug Transporter ABCG2 in Breast Cancer: Database Screening, Molecular Docking, and Molecular Dynamics Study.” | 0.98 | phenotype_alias_lexicon_v2 |
Prospective Drug Candidates as Human Multidrug Transporter ABCG2 Inhibitors: an In Silico Drug Discovery Study.
PMID 33954893 | DOI 10.1007/s12013-021-00985-y · Cell biochemistry and biophysics · 2021 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ABCG2 | “Prospective Drug Candidates as Human Multidrug Transporter ABCG2 Inhibitors: an In Silico Drug Discovery Study.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Breast cancer resistance protein (ABCG2) is a human ATP-binding cassette (ABC) that plays a paramount role in multidrug resistance (MDR) in cancer therapy.” | 0.98 | phenotype_alias_lexicon_v2 |
Association between ABCB1, ABCG2 carrier protein and COX-2 enzyme gene polymorphisms and breast cancer risk in a Turkish population.
PMID 32042261 | PMCID PMC7000306 | DOI 10.1016/j.jsps.2019.11.024 · Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ABCG2 | “Association between ABCB1, ABCG2 carrier protein and COX-2 enzyme gene polymorphisms and breast cancer risk in a Turkish population.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Association between ABCB1, ABCG2 carrier protein and COX-2 enzyme gene polymorphisms and breast cancer risk in a Turkish population.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | ABCB1 | “Association between ABCB1, ABCG2 carrier protein and COX-2 enzyme gene polymorphisms and breast cancer risk in a Turkish population.” | 0.98 | hgnc_dict_v1 |
| variant | rs2231142 | “METHOD: ABCG2 C421A (rs2231142), ABCB1 C3435T (rs1045642), COX-2 T8473C (rs5275) and COX-2 G306C (rs5277) were genotyped 104 breast cancer patients and 90 healthy controls using a real-time PCR for breast cancer susceptibility.” | 0.90 | hgvs_regex_v1 |
Role of Four ABC Transporter Genes in Pharmacogenetic Susceptibility to Breast Cancer in Jordanian Patients.
PMID 31391850 | PMCID PMC6662487 | DOI 10.1155/2019/6425708 · Journal of oncology · 2019 · 11 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ABCG2 | “In the present study, single nucleotide polymorphisms (SNPs) from the ABCC1, ABCC2, ABCB1, and ABCG2 genes were screened in breast cancer patients and healthy volunteers from the Jordanian-Arab population.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Role of Four ABC Transporter Genes in Pharmacogenetic Susceptibility to Breast Cancer in Jordanian Patients.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | ABCC1 | “In the present study, single nucleotide polymorphisms (SNPs) from the ABCC1, ABCC2, ABCB1, and ABCG2 genes were screened in breast cancer patients and healthy volunteers from the Jordanian-Arab population.” | 0.98 | hgnc_dict_v1 |
| gene | ABCC2 | “In the present study, single nucleotide polymorphisms (SNPs) from the ABCC1, ABCC2, ABCB1, and ABCG2 genes were screened in breast cancer patients and healthy volunteers from the Jordanian-Arab population.” | 0.98 | hgnc_dict_v1 |