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ABCG5 and diabetes mellitus are reported together in 2 articles.
Gene
ABCG5
- HGNC
- HGNC:13886
8articles
8mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Diabetes mellitus
2,156articles
2,156mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Whole exome sequencing identifies concurrent LDLR and ABCG8 mutations in a Saudi family with familial hypercholesterolemia and Sitosterolaemia.
PMID 41170196 | PMCID PMC12571453 | DOI 10.3389/fgene.2025.1679594 · Frontiers in genetics · 2025 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ABCG5 | “It is typically inherited in an autosomal dominant pattern due to mutations in the low-density lipoprotein receptor (LDLR) gene, whereas sitosterolemia follows an autosomal recessive mode associated with mutations in the ATP-binding cassette transporters (ABCG5 and ABCG8).” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “METHODS: A multigenerational family was recruited from the Diabetes and Endocrinology Center in Jazan, Saudi Arabia.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | LDLR | “Whole exome sequencing identifies concurrent LDLR and ABCG8 mutations in a Saudi family with familial hypercholesterolemia and Sitosterolaemia.” | 0.98 | hgnc_dict_v1 |
| gene | ABCG8 | “Whole exome sequencing identifies concurrent LDLR and ABCG8 mutations in a Saudi family with familial hypercholesterolemia and Sitosterolaemia.” | 0.98 | hgnc_dict_v1 |
Natural Compounds from Hatikana Extract Potentiate Antidiabetic Actions as Displayed by In Vivo Assays and Verified by Network Pharmacological Tools.
PMID 34725640 | PMCID PMC8557063 | DOI 10.1155/2021/6978450 · BioMed research international · 2021 · 27 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ABCG5 | “Oleanolic acid interacted with the proteins AKR1B10, CASP3, CASP8, CYP1A2, CYP1A2, HMGB1, NAMPT, NFE2L2, NQO1, PPARA, PTGIR, TOP1, TOP2A, UGT2B10, and UGT2B11 and stigmasterol with ABCA1, ABCG5, ABCG8, CTSE, HMGCR, IL10, CXCL8, NR1H2, NR1H3, SLCO1B1, SREBF2, and TNF.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Pathway analysis identified 31 KEGG metabolic, signaling, and immunogenic pathways associated with diabetes.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | SOD1 | “Following intervention, blood serum was examined for biochemical markers, and liver tissue was investigated for the mRNA expression of catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD1) by RTPCR analysis.” | 0.98 | hgnc_dict_v1 |
| gene | AKR1B10 | “Oleanolic acid interacted with the proteins AKR1B10, CASP3, CASP8, CYP1A2, CYP1A2, HMGB1, NAMPT, NFE2L2, NQO1, PPARA, PTGIR, TOP1, TOP2A, UGT2B10, and UGT2B11 and stigmasterol with ABCA1, ABCG5, ABCG8, CTSE, HMGCR, IL10, CXCL8, NR1H2, NR1H3, SLCO1B1, SREBF2, and TNF.” | 0.98 | hgnc_dict_v1 |