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ACE and MERS are reported together in 1 article.
Gene
ACE
- HGNC
- HGNC:2707
63articles
63mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
diabetes mellitus 13COVID-19 8hypertension 7coronary artery disease 6obesity 5renal failure 4pre-eclampsia 3congenital heart disease 2
Reported variants (articles · ClinVar status)
Phenotype
MERS
230articles
230mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60SARS-CoV-2 infections and COVID-19 mortalities strongly correlate with ACE1 I/D genotype.
PMID 32628976 | PMCID PMC7833925 | DOI 10.1016/j.gene.2020.144944 · Gene · 2020 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ACE | “For this reason, we investigated the involvement of genetic factors associated with SARS-CoV-2 infection with a focus on angiotensin-converting enzyme (ACE)-related genes, because ACE2 is a receptor for SARS-CoV-2.” | 0.98 | hgnc_dict_v1 |
| phenotype | MERS | “This has not been experienced in past global viral infections, such as influenza, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) and is unique to SARS-CoV-2.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | ACE2 | “For this reason, we investigated the involvement of genetic factors associated with SARS-CoV-2 infection with a focus on angiotensin-converting enzyme (ACE)-related genes, because ACE2 is a receptor for SARS-CoV-2.” | 0.98 | hgnc_dict_v1 |
| phenotype | COVID-19 | “SARS-CoV-2 infections and COVID-19 mortalities strongly correlate with ACE1 I/D genotype.” | 0.98 | phenotype_alias_lexicon_v2 |