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ACE and congenital heart disease are reported together in 2 articles.
Gene
ACE
- HGNC
- HGNC:2707
63articles
63mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
diabetes mellitus 13COVID-19 8hypertension 7coronary artery disease 6obesity 5renal failure 4pre-eclampsia 3congenital heart disease 2
Reported variants (articles · ClinVar status)
Phenotype
Congenital heart disease
363articles
363mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism in Egyptian children with congenital heart disease.
PMID 32343056 | DOI 10.1002/bdr2.1700 · Birth defects research · 2020 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ACE | “Angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism in Egyptian children with congenital heart disease.” | 0.98 | hgnc_dict_v1 |
| phenotype | congenital heart disease | “Angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism in Egyptian children with congenital heart disease.” | 0.98 | phenotype_alias_lexicon_v2 |
Angiotensin-converting enzyme gene insertion deletion (ACE I/D) polymorphism in Saudi children with congenital heart disease.
PMID 26125265 · European review for medical and pharmacological sciences · 2015 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ACE | “Angiotensin-converting enzyme gene insertion deletion (ACE I/D) polymorphism in Saudi children with congenital heart disease.” | 0.98 | hgnc_dict_v1 |
| phenotype | congenital heart disease | “Angiotensin-converting enzyme gene insertion deletion (ACE I/D) polymorphism in Saudi children with congenital heart disease.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Angiotensin-converting enzyme gene insertion deletion (ACE I/D) polymorphism in Saudi children with congenital heart disease. The aim of this work is to determine the normal distribution of I/D polymorphism in Saudi citizens and to test for any association between this polymorphism and CHDs in Saudi children. PATIENTS AND METHODS: Ninety-six CHD cases and 145 controls were included in this study. CONCLUSIONS: ACE I/D gene polymorphism is not associated with CHDs in Saudi children.” | 0.95 | saudi_context_rules_v1 |