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ACE and nephrotic syndrome are reported together in 1 article.
Gene
ACE
- HGNC
- HGNC:2707
63articles
63mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
diabetes mellitus 13COVID-19 8hypertension 7coronary artery disease 6obesity 5renal failure 4pre-eclampsia 3congenital heart disease 2
Reported variants (articles · ClinVar status)
Phenotype
Nephrotic syndrome
108articles
108mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Angiotensin-converting enzyme insertion/deletion gene polymorphism in children with nephrotic syndrome: Genotype-phenotype correlations.
PMID 41914989 | DOI 10.4103/sjkdt.sjkdt_726_20 · Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia · 2026 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ACE | “The angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) gene polymorphism has been studied for its possible role in INS in different ethnic groups with conflicting results reported.” | 0.98 | hgnc_dict_v1 |
| phenotype | nephrotic syndrome | “Angiotensin-converting enzyme insertion/deletion gene polymorphism in children with nephrotic syndrome: Genotype-phenotype correlations.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | INS | “PURPOSE: Detecting the genetic etiology of idiopathic nephrotic syndrome (INS) in different ethnic groups, especially in steroid-resistant subjects, is currently essential for individualized management, predicting prognosis, and family counseling.” | 0.98 | hgnc_dict_v1 |
| phenotype | hypertension | “DD genotype was also more frequent in patients with hypertension compared to non-hypertensive subjects (P = 0.03) and also in patients who progressed to renal impairment (P = 0.04).” | 0.98 | phenotype_alias_lexicon_v2 |