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ACE and stroke are reported together in 2 articles.
Gene
ACE
- HGNC
- HGNC:2707
63articles
63mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
diabetes mellitus 13COVID-19 8hypertension 7coronary artery disease 6obesity 5renal failure 4pre-eclampsia 3congenital heart disease 2
Reported variants (articles · ClinVar status)
Phenotype
Stroke
555articles
555mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Clinical exome sequencing identifies novel gene variants associated with ischemic stroke in the Saudi Tabuk population.
PMID 41676086 | PMCID PMC12886448 | DOI 10.3389/fnhum.2025.1645598 · Frontiers in human neuroscience · 2025 · 14 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ACE | “Also, several common gene variants were reported in MTHFR, KLF14, eNOS3, and ACE by whole-exome sequencing.” | 0.98 | hgnc_dict_v1 |
| phenotype | stroke | “Clinical exome sequencing identifies novel gene variants associated with ischemic stroke in the Saudi Tabuk population.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | GSTT4 | “RESULTS: Results identified 11 novel gene variants in the GSTT4 gene by targeted whole-exome sequencing, including one deletion GSTT4p.Asn232LysfsTer6, one insertion c.688_689insCG, and 9 SNVs c.699 T > C, c.701C > G, c.708G > T, c.710 T > G, c.712A > G, c.712A > G, c.718A > T, c.719G > A, c.721A > T, c.722G > T in the ischemic stroke patients.” | 0.98 | hgnc_dict_v1 |
| gene | LDLR | “We also identified several rare, intermediate, and most common gene variants in cholesterol associated genes LDLR, LDLRAD2, LDLRAD3, APOA2, APOA3, APOA4, APOA5, and PCSK9.” | 0.98 | hgnc_dict_v1 |
Angiotensin converting enzyme polymorphism and ischemic stroke.
PMID 32683396 | PMCID PMC8015476 | DOI 10.17712/nsj.2020.3.20190117 · Neurosciences (Riyadh, Saudi Arabia) · 2020 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ACE | “OBJECTIVE: To assess the polymorphism of angiotensin converting enzyme (ACE) in ischemic stroke in an Egyptian sample.” | 0.98 | hgnc_dict_v1 |
| phenotype | stroke | “Angiotensin converting enzyme polymorphism and ischemic stroke.” | 0.98 | phenotype_alias_lexicon_v2 |