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Every result shows the extracted entities next to the sentences that support them; rows for the searched entities come first.
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ACE2 and malaria are reported together in 1 article.
Gene
ACE2
- HGNC
- HGNC:13557
115articles
115mentions
10variants with confirmed gene link (top 10)
Most co-reported phenotypes (articles)
COVID-19 81SARS 30hypertension 8MERS 6diabetes mellitus 6obesity 6coronary artery disease 3lung cancer 2
Reported variants (articles · ClinVar status)
Phenotype
Malaria
232articles
232mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Chloroquine and Hydroxychloroquine Interact Differently with ACE2 Domains Reported to Bind with the Coronavirus Spike Protein: Mediation by ACE2 Polymorphism.
PMID 33525415 | PMCID PMC7865913 | DOI 10.3390/molecules26030673 · Molecules (Basel, Switzerland) · 2021 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ACE2 | “Chloroquine and Hydroxychloroquine Interact Differently with ACE2 Domains Reported to Bind with the Coronavirus Spike Protein: Mediation by ACE2 Polymorphism.” | 0.98 | hgnc_dict_v1 |
| phenotype | malaria | “Chloroquine (CQ) and its metabolite hydroxychloroquine (HCQ) are mainly used to prevent and treat malaria and rheumatic diseases.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | COVID-19 | “The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection inducing coronavirus disease 2019 (COVID-19) is still an ongoing challenge.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | SARS | “The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection inducing coronavirus disease 2019 (COVID-19) is still an ongoing challenge.” | 0.93 | phenotype_alias_lexicon_v2 |