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ACSL4 and infertility are reported together in 1 article.
Gene
ACSL4
- HGNC
- HGNC:3571
3articles
3mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Infertility
199articles
199mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Morin hydrate protects against cisplatin-induced testicular toxicity by modulating ferroptosis and steroidogenesis genes' expression and upregulating Nrf2/Heme oxygenase-1.
PMID 40595313 | PMCID PMC12217244 | DOI 10.1038/s41598-025-08235-4 · Scientific reports · 2025 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ACSL4 | “Moreover, MH inhibited cisplatin-induced ferroptosis via the modulation of ferroptosis genes' expression (ACSL4, SLC7A11, and TFRC) and the reduction of iron accumulation in testicular tissue.” | 0.98 | hgnc_dict_v1 |
| phenotype | infertility | “This study points out that MH might mitigate iron-mediated apoptosis through the downregulation of Nrf2/HO-1 signaling, providing a potential therapeutic strategy for preventing infertility in male patients undergoing cisplatin chemotherapy.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | SLC7A11 | “Moreover, MH inhibited cisplatin-induced ferroptosis via the modulation of ferroptosis genes' expression (ACSL4, SLC7A11, and TFRC) and the reduction of iron accumulation in testicular tissue.” | 0.98 | hgnc_dict_v1 |
| gene | TFRC | “Moreover, MH inhibited cisplatin-induced ferroptosis via the modulation of ferroptosis genes' expression (ACSL4, SLC7A11, and TFRC) and the reduction of iron accumulation in testicular tissue.” | 0.98 | hgnc_dict_v1 |