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ADAM10 and intellectual disability are reported together in 2 articles.
Gene
ADAM10
- HGNC
- HGNC:188
10articles
10mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Intellectual disability
- HPO
- HP:0001249
736articles
736mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Cognitive function and retinal biomarkers as novel approach to diagnosing and assessing autism spectrum disorder.
PMID 40410251 | PMCID PMC12102242 | DOI 10.1038/s41598-025-03062-z · Scientific reports · 2025 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ADAM10 | “80 children were recruited to test biomarkers of the retinal function, Ciliary neurotrophic factor (CNTF), and cognitive function A Disintegrin and Metalloproteases 10 (ADAM10).” | 0.98 | hgnc_dict_v1 |
| phenotype | intellectual disability | “The retina is invariably considered an extension of the central nervous system and can predict cognitive impairment in neurodevelopmental and neurodegenerative disorders.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CNTF | “80 children were recruited to test biomarkers of the retinal function, Ciliary neurotrophic factor (CNTF), and cognitive function A Disintegrin and Metalloproteases 10 (ADAM10).” | 0.98 | hgnc_dict_v1 |
| phenotype | autism spectrum disorder | “Cognitive function and retinal biomarkers as novel approach to diagnosing and assessing autism spectrum disorder.” | 0.98 | phenotype_alias_lexicon_v2 |
Molecular physiology unlocks the mystery that relates cognitive impairment with the retina in schizophrenia and autism spectrum disorders: a perspective review.
PMID 39588547 | PMCID PMC11586360 | DOI 10.3389/fpsyt.2024.1495017 · Frontiers in psychiatry · 2024 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ADAM10 | “It also discusses the possible involvement of the retina and molecular biomarkers, specifically Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) and ciliary neurotrophic factor (CNTF) in the pathophysiology of SSD and ASD.” | 0.98 | hgnc_dict_v1 |
| phenotype | intellectual disability | “Molecular physiology unlocks the mystery that relates cognitive impairment with the retina in schizophrenia and autism spectrum disorders: a perspective review.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CNTF | “It also discusses the possible involvement of the retina and molecular biomarkers, specifically Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) and ciliary neurotrophic factor (CNTF) in the pathophysiology of SSD and ASD.” | 0.98 | hgnc_dict_v1 |
| phenotype | autism spectrum disorder | “Molecular physiology unlocks the mystery that relates cognitive impairment with the retina in schizophrenia and autism spectrum disorders: a perspective review.” | 0.93 | phenotype_alias_lexicon_v2 |