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ADAM10 and pre-eclampsia are reported together in 1 article.
Gene
ADAM10
- HGNC
- HGNC:188
10articles
10mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Pre-eclampsia
84articles
84mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia.
PMID 25031267 | DOI 10.1126/scitranslmed.3008808 · Science translational medicine · 2014 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ADAM10 | “The human placenta abundantly expresses APP along with prototype APP-processing enzymes, of which the α-secretase ADAM10, the β-secretases BACE1 and BACE2, and the γ-secretase presenilin-1 were all up-regulated in preeclampsia.” | 0.98 | hgnc_dict_v1 |
| phenotype | pre-eclampsia | “Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | SERPINA1 | “In the first attempt to characterize the preeclampsia misfoldome, we report that the urine congophilic material includes proteoforms of ceruloplasmin, immunoglobulin free light chains, SERPINA1, albumin, interferon-inducible protein 6-16, and Alzheimer's β-amyloid.” | 0.98 | hgnc_dict_v1 |
| gene | BACE1 | “The human placenta abundantly expresses APP along with prototype APP-processing enzymes, of which the α-secretase ADAM10, the β-secretases BACE1 and BACE2, and the γ-secretase presenilin-1 were all up-regulated in preeclampsia.” | 0.98 | hgnc_dict_v1 |