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AKT1 and Alzheimer disease are reported together in 3 articles.
Gene
AKT1
- HGNC
- HGNC:391
63articles
63mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Alzheimer disease
455articles
455mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Decoding apoptosis-associated pathways in inflammatory and neurodegenerative diseases: A network pharmacology based drug discovery approach.
PMID 41082993 | DOI 10.1016/j.ejphar.2025.178231 · European journal of pharmacology · 2025 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | AKT1 | “Subsequently, protein-protein interaction (PPI) network analysis identified top hub genes including AKT1, CASP3, TNF, and BCL2 as central to disease modulation.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Neurodegenerative diseases, particularly Alzheimer's disease (AD), continue to pose significant global health challenges due to their progressive nature, multifactorial etiology, and limited therapeutic options.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CASP3 | “Subsequently, protein-protein interaction (PPI) network analysis identified top hub genes including AKT1, CASP3, TNF, and BCL2 as central to disease modulation.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Subsequently, protein-protein interaction (PPI) network analysis identified top hub genes including AKT1, CASP3, TNF, and BCL2 as central to disease modulation.” | 0.98 | hgnc_dict_v1 |
SG06, a Chalcone Derivative Targets PI3K/AKT1 Pathway for Neuroprotection and Cognitive Enhancement in an Alzheimer's Disease-Like Zebrafish Model.
PMID 40346444 | DOI 10.1007/s12035-025-05023-z · Molecular neurobiology · 2025 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | AKT1 | “SG06, a Chalcone Derivative Targets PI3K/AKT1 Pathway for Neuroprotection and Cognitive Enhancement in an Alzheimer's Disease-Like Zebrafish Model.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Alzheimer's disease (AD) and Alzheimer's dementia (ADM) are common neurodegenerative disorders marked by progressive cognitive decline, memory impairment, and behavioral deficits, which impose a significant burden on individuals and healthcare systems worldwide.” | 0.93 | phenotype_alias_lexicon_v2 |
Defining the Role of Isoeugenol from Ocimum tenuiflorum against Diabetes Mellitus-Linked Alzheimer's Disease through Network Pharmacology and Computational Methods.
PMID 35458596 | PMCID PMC9025232 | DOI 10.3390/molecules27082398 · Molecules (Basel, Switzerland) · 2022 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | AKT1 | “Among these 14 genes, GAPDH and AKT1 were the most significant.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Defining the Role of Isoeugenol from Ocimum tenuiflorum against Diabetes Mellitus-Linked Alzheimer's Disease through Network Pharmacology and Computational Methods.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | GAPDH | “Among these 14 genes, GAPDH and AKT1 were the most significant.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Defining the Role of Isoeugenol from Ocimum tenuiflorum against Diabetes Mellitus-Linked Alzheimer's Disease through Network Pharmacology and Computational Methods.” | 0.93 | phenotype_alias_lexicon_v2 |