Advanced search
Combine gene, variant, phenotype, region and year filters
Every result shows the extracted entities next to the sentences that support them; rows for the searched entities come first.
Transparent by designEvery result links extracted entities to its source sentence and publication identifier.
Knowledge-base search
About your search
AKT1 and diabetes mellitus are reported together in 6 articles.
Gene
AKT1
- HGNC
- HGNC:391
63articles
63mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Diabetes mellitus
2,156articles
2,156mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
6 records shown · first 60Deciphering the Anti-Diabetic Potential of Gymnema Sylvestre Using Integrated Computer-Aided Drug Design and Network Pharmacology.
PMID 39810481 | PMCID PMC11733079 | DOI 10.1111/jcmm.70349 · Journal of cellular and molecular medicine · 2025 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | AKT1 | “The protein-protein interaction network, constructed via the STRING database, underwent topological analysis in Cytoscape, identifying AKT1, SRC, TNF, PPARG and IL1B as top targets.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “This study explores novel therapeutic avenues for diabetes, a global health concern marked by elevated blood glucose levels.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | PPARG | “The protein-protein interaction network, constructed via the STRING database, underwent topological analysis in Cytoscape, identifying AKT1, SRC, TNF, PPARG and IL1B as top targets.” | 0.98 | hgnc_dict_v1 |
| gene | IL1B | “The protein-protein interaction network, constructed via the STRING database, underwent topological analysis in Cytoscape, identifying AKT1, SRC, TNF, PPARG and IL1B as top targets.” | 0.98 | hgnc_dict_v1 |
Circulating hsa-miR-320a and its regulatory network in type 1 diabetes mellitus.
PMID 39464889 | PMCID PMC11502356 | DOI 10.3389/fimmu.2024.1376416 · Frontiers in immunology · 2024 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | AKT1 | “Our analysis revealed that hsa-miR-320a-3p and its key targets, including PTEN, AKT1, BCL2, FOXO1 and MYC, are dysregulated in T1D, along with their interacting partners namely BLIMP3, GSK3B, CAV1, CXCL3, TGFB, and IL10.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Circulating hsa-miR-320a and its regulatory network in type 1 diabetes mellitus.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | PTEN | “Our analysis revealed that hsa-miR-320a-3p and its key targets, including PTEN, AKT1, BCL2, FOXO1 and MYC, are dysregulated in T1D, along with their interacting partners namely BLIMP3, GSK3B, CAV1, CXCL3, TGFB, and IL10.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Our analysis revealed that hsa-miR-320a-3p and its key targets, including PTEN, AKT1, BCL2, FOXO1 and MYC, are dysregulated in T1D, along with their interacting partners namely BLIMP3, GSK3B, CAV1, CXCL3, TGFB, and IL10.” | 0.98 | hgnc_dict_v1 |
Forecasting the Pharmacological Mechanisms of Plumbago zeylanica and Solanum xanthocarpum in Diabetic Retinopathy Treatment: A Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation Study.
PMID 39336159 | PMCID PMC11429473 | DOI 10.3390/biology13090732 · Biology · 2024 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | AKT1 | “Pathway enrichment was performed with Gene Ontology and KEGG databases; (3) Results: We identified 28 active phytoconstituents, targeting proteins such as EGFR, SRC, STAT3, AKT1, and HSP90AA1.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Forecasting the Pharmacological Mechanisms of Plumbago zeylanica and Solanum xanthocarpum in Diabetic Retinopathy Treatment: A Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation Study. (1) Background: Diabetic retinopathy (DR) is a major complication of diabetes, marked by abnormal angiogenesis, microaneurysms, and retinal hemorrhages.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | EGFR | “Pathway enrichment was performed with Gene Ontology and KEGG databases; (3) Results: We identified 28 active phytoconstituents, targeting proteins such as EGFR, SRC, STAT3, AKT1, and HSP90AA1.” | 0.98 | hgnc_dict_v1 |
| gene | SRC | “Pathway enrichment was performed with Gene Ontology and KEGG databases; (3) Results: We identified 28 active phytoconstituents, targeting proteins such as EGFR, SRC, STAT3, AKT1, and HSP90AA1.” | 0.98 | hgnc_dict_v1 |
Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulations Reveal the Mechanisms of Cinnamomum tamala in Diabetic Nephropathy Treatment: An In Silico Study.
PMID 39590299 | PMCID PMC11592827 | DOI 10.3390/cimb46110705 · Current issues in molecular biology · 2024 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | AKT1 | “Key targets like MMP9, EGFR, and AKT1 were highlighted, and the PPAR and PI3K-AKT signaling pathways were identified as the primary mechanisms through which CT may treat DN.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Cinnamomum tamala (CT), traditionally used in managing diabetes and kidney disorders, has shown potential in treating DN, although its active compounds and mechanisms are not fully understood.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | MMP9 | “Key targets like MMP9, EGFR, and AKT1 were highlighted, and the PPAR and PI3K-AKT signaling pathways were identified as the primary mechanisms through which CT may treat DN.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Key targets like MMP9, EGFR, and AKT1 were highlighted, and the PPAR and PI3K-AKT signaling pathways were identified as the primary mechanisms through which CT may treat DN.” | 0.98 | hgnc_dict_v1 |
Integrating Network Pharmacology and Molecular Docking Approaches to Decipher the Multi-Target Pharmacological Mechanism of Abrus precatorius L. Acting on Diabetes.
PMID 35455411 | PMCID PMC9029140 | DOI 10.3390/ph15040414 · Pharmaceuticals (Basel, Switzerland) · 2022 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | AKT1 | “In the framework of this study, we explored the active ingredient-target-pathway network and figured out that abrectorin, abrusin, abrisapogenol J, sophoradiol, cholanoic acid, precatorine, and cycloartenol decisively contributed to the development of T2DM by affecting AKT1, MAPK3, TNFalpha, and MAPK1 genes.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Acting on Diabetes.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | MAPK3 | “In the framework of this study, we explored the active ingredient-target-pathway network and figured out that abrectorin, abrusin, abrisapogenol J, sophoradiol, cholanoic acid, precatorine, and cycloartenol decisively contributed to the development of T2DM by affecting AKT1, MAPK3, TNFalpha, and MAPK1 genes.” | 0.98 | hgnc_dict_v1 |
| gene | MAPK1 | “In the framework of this study, we explored the active ingredient-target-pathway network and figured out that abrectorin, abrusin, abrisapogenol J, sophoradiol, cholanoic acid, precatorine, and cycloartenol decisively contributed to the development of T2DM by affecting AKT1, MAPK3, TNFalpha, and MAPK1 genes.” | 0.98 | hgnc_dict_v1 |
Defining the Role of Isoeugenol from Ocimum tenuiflorum against Diabetes Mellitus-Linked Alzheimer's Disease through Network Pharmacology and Computational Methods.
PMID 35458596 | PMCID PMC9025232 | DOI 10.3390/molecules27082398 · Molecules (Basel, Switzerland) · 2022 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | AKT1 | “Among these 14 genes, GAPDH and AKT1 were the most significant.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Defining the Role of Isoeugenol from Ocimum tenuiflorum against Diabetes Mellitus-Linked Alzheimer's Disease through Network Pharmacology and Computational Methods.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | GAPDH | “Among these 14 genes, GAPDH and AKT1 were the most significant.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Defining the Role of Isoeugenol from Ocimum tenuiflorum against Diabetes Mellitus-Linked Alzheimer's Disease through Network Pharmacology and Computational Methods.” | 0.93 | phenotype_alias_lexicon_v2 |