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AKT1 and epilepsy are reported together in 1 article.
Gene
AKT1
- HGNC
- HGNC:391
63articles
63mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Epilepsy
- HPO
- HP:0001250
2,084articles
2,084mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Facile synthesis of (4-phenylthiophen-2-yl)methyl 1-naphthoates via Suzuki-Miyaura cross-coupling: anti-seizure evaluation through molecular docking, EEG analysis, and ADMET profiling.
PMID 42181711 | PMCID PMC13195418 | DOI 10.1039/d6ra02094a · RSC advances · 2026 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | AKT1 | “By focusing on hub genes (SRC, AKT1, MAPK1/3, STAT3, EGFR) implicated in key signaling pathways such as PI3K-Akt, MAPK, JAK-STAT, and GABAergic synapse signaling, network analysis showed that these drugs had 15-25 targets in common with epilepsy.” | 0.98 | hgnc_dict_v1 |
| phenotype | epilepsy | “By focusing on hub genes (SRC, AKT1, MAPK1/3, STAT3, EGFR) implicated in key signaling pathways such as PI3K-Akt, MAPK, JAK-STAT, and GABAergic synapse signaling, network analysis showed that these drugs had 15-25 targets in common with epilepsy.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | SV2A | “In addition, the goal of the current study was to use a multifaceted strategy that integrates molecular docking (AutoDock Vina), in silico ADMET (SwissADME, Molsoft), and network pharmacology to explore their potential as anti-epileptic drugs against important targets (GABAA receptor (8G5G), SV2A (3O7P, 1PW4)).” | 0.98 | hgnc_dict_v1 |
| gene | SRC | “By focusing on hub genes (SRC, AKT1, MAPK1/3, STAT3, EGFR) implicated in key signaling pathways such as PI3K-Akt, MAPK, JAK-STAT, and GABAergic synapse signaling, network analysis showed that these drugs had 15-25 targets in common with epilepsy.” | 0.98 | hgnc_dict_v1 |