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AKT1 and obesity are reported together in 1 article.
Gene
AKT1
- HGNC
- HGNC:391
63articles
63mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Obesity
- HPO
- HP:0001513
856articles
856mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Exploring therapeutic targets and drug candidates for obesity: a combined network pharmacology, bioinformatics approach.
PMID 37811763 | DOI 10.1080/07391102.2023.2265491 · Journal of biomolecular structure & dynamics · 2024 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | AKT1 | “We systematically compiled compound data from public databases and reviewed literature, revealing active compounds like apigenin, kaempferol, moupinamide, cyclocurcumin, chrysoeriol, isorhamnetin, rheinanthrone, cyclocurcumin, and riboflavin.Constructing a compound-target genes-obesity network unveiled their significant impact on metabolic regulation and fat accumulation, interacting notably with key proteins AKT1 and PTGS2.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “Exploring therapeutic targets and drug candidates for obesity: a combined network pharmacology, bioinformatics approach.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | PTGS2 | “We systematically compiled compound data from public databases and reviewed literature, revealing active compounds like apigenin, kaempferol, moupinamide, cyclocurcumin, chrysoeriol, isorhamnetin, rheinanthrone, cyclocurcumin, and riboflavin.Constructing a compound-target genes-obesity network unveiled their significant impact on metabolic regulation and fat accumulation, interacting notably with key proteins AKT1 and PTGS2.” | 0.98 | hgnc_dict_v1 |
| population | Saudi Arabia | “The remarkably high prevalence of obesity in Saudi Arabia reflects a global epidemic demanding urgent attention due to its associated health risks. Employing adipocytes as a cellular model, we gauged their viability and response to obesity-related stressors post-treatment with these native plant compounds.In conclusion, Saudi Arabia's indigenous plants hold promise as natural solutions for obesity treatment.” | 0.95 | saudi_context_rules_v1 |