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ANGPTL8 and metabolic syndrome are reported together in 1 article.
Gene
ANGPTL8
- HGNC
- HGNC:24933
3articles
3mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
Reported variants (articles · ClinVar status)
Phenotype
Metabolic syndrome
141articles
141mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Association of ANGPTL8 (Betatrophin) Gene Variants with Components of Metabolic Syndrome in Arab Adults.
PMID 32317770 | PMCID PMC7174409 | DOI 10.1038/s41598-020-63850-7 · Scientific reports · 2020 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ANGPTL8 | “Association of ANGPTL8 (Betatrophin) Gene Variants with Components of Metabolic Syndrome in Arab Adults.” | 0.98 | hgnc_dict_v1 |
| phenotype | metabolic syndrome | “Association of ANGPTL8 (Betatrophin) Gene Variants with Components of Metabolic Syndrome in Arab Adults.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | diabetes mellitus | “Angiopoietin-like protein 8 (ANGPTL8) has a role in lipid metabolism, beta-cell proliferation and diabetes progression, however, the association between different variants in the ANGPTL8 gene and metabolic syndrome (MetS) components has not been studied widely especially in Arab ethnic groups.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | familial hypercholesterolemia | “Furthermore, the TC + CC genotype and C allele of rs737337 (T/C) was associated with decreased risk of hypercholesterolemia and hyperglycemia [odds ratio (OR) 0.61, 95%CI 0.40-0.93, p = 0.016 and OR 0.58, 0.39-0.86, p = 0.007 respectively for hypercholesterolemia; and OR 0.66, 0.45-0.97, p = 0.032 and OR 0.65, 0.46-0.93; p = 0.016 respectively for hyperglycemia].” | 0.93 | phenotype_alias_lexicon_v2 |