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APC and breast cancer are reported together in 1 article.
Gene
APC
- HGNC
- HGNC:583
44articles
44mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
colorectal cancer 24lung cancer 4breast cancer 1diabetes mellitus 1hepatitis C 1infertility 1obesity 1ovarian cancer 1
Reported variants (articles · ClinVar status)
Phenotype
Breast cancer
1,211articles
1,211mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60High-frequency deregulated expression of Wnt signaling pathway members in breast carcinomas.
PMID 29391809 | PMCID PMC5769582 | DOI 10.2147/OTT.S154395 · OncoTargets and therapy · 2018 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | APC | “MATERIALS AND METHODS: We immunohistochemically examined various components of Wnt signaling pathway including β-catenin, tumor suppressor proteins, adenomatous polyposis coli (APC), and Axin, expression of naturally occurring pathway antagonists such as Dickkopf Wnt signaling pathway inhibitor 3 (DKK3), FRP2, and WIF1, as well as Wnt target cyclin D1 and c-Myc to establish if the pathway is constitutively activated in breast cancers arising in Saudi women.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “PURPOSE: Breast carcinoma is the most common malignancy and leading cause of cancer-related deaths in women worldwide including Saudi Arabia.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | DKK3 | “MATERIALS AND METHODS: We immunohistochemically examined various components of Wnt signaling pathway including β-catenin, tumor suppressor proteins, adenomatous polyposis coli (APC), and Axin, expression of naturally occurring pathway antagonists such as Dickkopf Wnt signaling pathway inhibitor 3 (DKK3), FRP2, and WIF1, as well as Wnt target cyclin D1 and c-Myc to establish if the pathway is constitutively activated in breast cancers arising in Saudi women.” | 0.98 | hgnc_dict_v1 |
| gene | WIF1 | “MATERIALS AND METHODS: We immunohistochemically examined various components of Wnt signaling pathway including β-catenin, tumor suppressor proteins, adenomatous polyposis coli (APC), and Axin, expression of naturally occurring pathway antagonists such as Dickkopf Wnt signaling pathway inhibitor 3 (DKK3), FRP2, and WIF1, as well as Wnt target cyclin D1 and c-Myc to establish if the pathway is constitutively activated in breast cancers arising in Saudi women.” | 0.98 | hgnc_dict_v1 |