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APC and diabetes mellitus are reported together in 1 article.
Gene
APC
- HGNC
- HGNC:583
44articles
44mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
colorectal cancer 24lung cancer 4breast cancer 1diabetes mellitus 1hepatitis C 1infertility 1obesity 1ovarian cancer 1
Reported variants (articles · ClinVar status)
Phenotype
Diabetes mellitus
2,156articles
2,156mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Eugenol: An Insight Into the Anticancer Perspective and Pharmacological Aspects.
PMID 40761498 | PMCID PMC12318832 | DOI 10.1002/fsn3.70727 · Food science & nutrition · 2025 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | APC | “The oncogenesis includes activation of pro-inflammatory markers (IL-6, IL-1β, TNF-α), resulting in overexpression of oncogenes, downregulation of tumor suppressor genes (TSGs) like p53, pRb, APC, PTEN, suppression of antioxidant enzymes (GSH, CAT, SOD), and activation of signaling pathways (PI3K/Akt/mTOR/NF-κB, Ras/MAPK).” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “These factors lead to oxidative stress (OS), inflammation, DNA damage, epigenetic and genetic mutations, cell proliferation, tumorigenesis, and other chronic metabolic disorders such as diabetes mellitus, cardiovascular disorders, gastrointestinal problems, and hepato-renal syndrome.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | PTEN | “The oncogenesis includes activation of pro-inflammatory markers (IL-6, IL-1β, TNF-α), resulting in overexpression of oncogenes, downregulation of tumor suppressor genes (TSGs) like p53, pRb, APC, PTEN, suppression of antioxidant enzymes (GSH, CAT, SOD), and activation of signaling pathways (PI3K/Akt/mTOR/NF-κB, Ras/MAPK).” | 0.98 | hgnc_dict_v1 |
| phenotype | colorectal cancer | “Among various types of cancers, lung cancer is leading them all, followed by breast and colorectal cancer (CRC).” | 0.98 | phenotype_alias_lexicon_v2 |