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APOB and diabetes mellitus are reported together in 2 articles.
Gene
APOB
- HGNC
- HGNC:603
22articles
22mentions
5variants with confirmed gene link
Most co-reported phenotypes (articles)
familial hypercholesterolemia 10coronary artery disease 3dyslipidemia 3diabetes mellitus 2hepatocellular carcinoma 2myocardial infarction 2cardiomyopathy 1obesity 1
Reported variants (articles · ClinVar status)
Phenotype
Diabetes mellitus
2,156articles
2,156mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Whole-Exomes Sequencing Delineates Gene Variants Profile in a Young Saudi Male with Familial Hypercholesterolemia: Case Report.
PMID 28764195 | PMCID PMC5535388 | DOI 10.7860/JCDR/2017/28156.10143 · Journal of clinical and diagnostic research : JCDR · 2017 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | APOB | “Albeit the diagnosis of some medical Familial Hypercholesterolemia (FH) cases are due to mutations in PCSK9, APOB, or LDLR, detection of mutation rate and profiles relies heavily on different gene pools and ethnicity.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “However, via variant reduction and TVC protocols we detected 15 new variants, among which 14 genes are linked to hypercholesterolemia, type-I, and type-II diabetes.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | PCSK9 | “Albeit the diagnosis of some medical Familial Hypercholesterolemia (FH) cases are due to mutations in PCSK9, APOB, or LDLR, detection of mutation rate and profiles relies heavily on different gene pools and ethnicity.” | 0.98 | hgnc_dict_v1 |
| gene | LDLR | “Albeit the diagnosis of some medical Familial Hypercholesterolemia (FH) cases are due to mutations in PCSK9, APOB, or LDLR, detection of mutation rate and profiles relies heavily on different gene pools and ethnicity.” | 0.98 | hgnc_dict_v1 |
The Spectrum of Familial Hypercholesterolemia (FH) in Saudi Arabia: Prime Time for Patient FH Registry.
PMID 28868092 | PMCID PMC5564019 | DOI 10.2174/1874192401711010066 · The open cardiovascular medicine journal · 2017 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | APOB | “The underlying molecular basis of FH is the presence of mutations in one or more genes in the low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB) or proprotein convertase subtilisin/kexin 9 (PCSK9).” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Furthermore, the high prevalence of obesity and diabetes mellitus in Saudi Arabia increases the vascular disease burden in FH cases by adding additional CVD risk factors.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | LDLR | “The underlying molecular basis of FH is the presence of mutations in one or more genes in the low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB) or proprotein convertase subtilisin/kexin 9 (PCSK9).” | 0.98 | hgnc_dict_v1 |
| gene | PCSK9 | “The underlying molecular basis of FH is the presence of mutations in one or more genes in the low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB) or proprotein convertase subtilisin/kexin 9 (PCSK9).” | 0.98 | hgnc_dict_v1 |