Advanced search
Combine gene, variant, phenotype, region and year filters
Every result shows the extracted entities next to the sentences that support them; rows for the searched entities come first.
Transparent by designEvery result links extracted entities to its source sentence and publication identifier.
Knowledge-base search
About your search
APOB and hepatocellular carcinoma are reported together in 2 articles.
Gene
APOB
- HGNC
- HGNC:603
22articles
22mentions
5variants with confirmed gene link
Most co-reported phenotypes (articles)
familial hypercholesterolemia 10coronary artery disease 3dyslipidemia 3diabetes mellitus 2hepatocellular carcinoma 2myocardial infarction 2cardiomyopathy 1obesity 1
Reported variants (articles · ClinVar status)
Phenotype
Hepatocellular carcinoma
417articles
417mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Carriage of rare APOB variants predisposes to severe steatotic liver disease and hepatocellular carcinoma.
PMID 41665936 | PMCID PMC13078886 | DOI 10.1172/JCI201762 · The Journal of clinical investigation · 2026 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | APOB | “Carriage of rare APOB variants predisposes to severe steatotic liver disease and hepatocellular carcinoma.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “Carriage of rare APOB variants predisposes to severe steatotic liver disease and hepatocellular carcinoma.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | MVP | “Rare variants in apolipoprotein B gene (APOB) have been implicated in susceptibility to liver steatosis, but their role in disease progression and outcomes is unclear.METHODSWe investigated APOB rare variants in a case-control cohort of people with advanced MASLD versus healthy controls (n = 510 and 261, respectively), a family-based study (n = 43 and literature meta-analysis), the Million Veteran Program (MVP) cohort (n = 94,885), and the UK Biobank (UKBB) (n = 417,657).RESULTSIn the clinical cohort, APOB variants were enriched in people with advanced MASLD (OR 13.8, 95% CI: 2.7-70.7, P = 0.002) and associated with lower circulating lipids, but higher MASLD activity and fibrosis (P < 0.05).” | 0.98 | hgnc_dict_v1 |
| phenotype | coronary artery disease | “Variants affecting specifically ApoB100 had a 3-fold greater effect on hepatic lipid metabolism compared with those impairing also ApoB48 and were specifically protective against coronary artery disease (P < 0.05).” | 0.98 | phenotype_alias_lexicon_v2 |
Genomic landscape in Saudi patients with hepatocellular carcinoma using whole-genome sequencing: a pilot study.
PMID 41821813 | PMCID PMC12952451 | DOI 10.3389/fgstr.2023.1205415 · Frontiers in gastroenterology (Lausanne, Switzerland) · 2023 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | APOB | “The study also revealed the presence of specific somatic aberrations, including TP53, PIK3CA, APOB, CTNNB1, DPYD, LRP1B, MYC, and NFE2L2, which were identified in two patients.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “Genomic landscape in Saudi patients with hepatocellular carcinoma using whole-genome sequencing: a pilot study.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TP53 | “The study also revealed the presence of specific somatic aberrations, including TP53, PIK3CA, APOB, CTNNB1, DPYD, LRP1B, MYC, and NFE2L2, which were identified in two patients.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “The study also revealed the presence of specific somatic aberrations, including TP53, PIK3CA, APOB, CTNNB1, DPYD, LRP1B, MYC, and NFE2L2, which were identified in two patients.” | 0.98 | hgnc_dict_v1 |