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APOB and stroke are reported together in 1 article.
Gene
APOB
- HGNC
- HGNC:603
22articles
22mentions
5variants with confirmed gene link
Most co-reported phenotypes (articles)
familial hypercholesterolemia 10coronary artery disease 3dyslipidemia 3diabetes mellitus 2hepatocellular carcinoma 2myocardial infarction 2cardiomyopathy 1obesity 1
Reported variants (articles · ClinVar status)
Phenotype
Stroke
555articles
555mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60New Insights into Genetic Polymorphisms Influencing the Therapeutic Efficacy and Toxicity of Rivaroxaban.
PMID 42394189 | DOI 10.1002/jcph.70236 · Journal of clinical pharmacology · 2026 · 11 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | APOB | “Furthermore, novel genetic polymorphisms in SUSD3 and APOB were associated with bleeding risk during rivaroxaban therapy.” | 0.98 | hgnc_dict_v1 |
| phenotype | stroke | “Thromboembolic diseases, including venous thromboembolism and atrial fibrillation-related stroke, represent a prevalent health concern and a risk for mortality and health care costs.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CYP3A4 | “CYP3A4 and CYP3A5 polymorphisms greatly impacted the pharmacokinetics of rivaroxaban; CYP2J2 polymorphisms were not greatly associated with the clinical outcome.” | 0.98 | hgnc_dict_v1 |
| gene | CYP3A5 | “CYP3A4 and CYP3A5 polymorphisms greatly impacted the pharmacokinetics of rivaroxaban; CYP2J2 polymorphisms were not greatly associated with the clinical outcome.” | 0.98 | hgnc_dict_v1 |