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APOE and diabetes mellitus are reported together in 6 articles.
Gene
APOE
- HGNC
- HGNC:613
46articles
46mentions
6variants with confirmed gene link
Most co-reported phenotypes (articles)
Alzheimer disease 18diabetes mellitus 6Parkinson disease 5dyslipidemia 5coronary artery disease 3stroke 3amyotrophic lateral sclerosis 2familial hypercholesterolemia 2
Reported variants (articles · ClinVar status)
Phenotype
Diabetes mellitus
2,156articles
2,156mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
6 records shown · first 60Relationships Between APOE, Type 2 Diabetes, and Cardiovascular Disease in Postmenopausal Women.
PMID 39364911 | PMCID PMC11775828 | DOI 10.1093/gerona/glae246 · The journals of gerontology. Series A, Biological sciences and medical sciences · 2025 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | APOE | “Relationships Between APOE, Type 2 Diabetes, and Cardiovascular Disease in Postmenopausal Women.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Relationships Between APOE, Type 2 Diabetes, and Cardiovascular Disease in Postmenopausal Women.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | stroke | “We examined associations of APOE status (APOE2+ [ε2/ε2, ε2/ε3], APOE3 [ε3/ε3], and APOE4+ [ε4/ε4, ε3/ε4] carriers) with incidence of T2DM, coronary heart disease, stroke, and total CVD events using Cox regression.” | 0.98 | phenotype_alias_lexicon_v2 |
Biochemical Investigation of the Association of Apolipoprotein E Gene Allele Variations with Insulin Resistance and Amyloid-β Aggregation in Cardiovascular Disease.
PMID 39582253 | DOI 10.1111/1440-1681.70007 · Clinical and experimental pharmacology & physiology · 2025 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | APOE | “This article investigates the intricate associations between apolipoprotein E (APOE) gene alleles variation, insulin resistance (IR) and amyloid-β aggregation in cardiovascular disease (CVD) patients.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “After applying the stringent inclusion and exclusion criteria, the diseased group was further stratified into three categories: CVD+ (Alzheimer's disease) AD, CVD + (diabetes mellitus) DM and CVD + DM + AD.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | Alzheimer disease | “After applying the stringent inclusion and exclusion criteria, the diseased group was further stratified into three categories: CVD+ (Alzheimer's disease) AD, CVD + (diabetes mellitus) DM and CVD + DM + AD.” | 0.93 | phenotype_alias_lexicon_v2 |
The link between Alzheimer's disease and stroke: A detrimental synergism.
PMID 38914265 | DOI 10.1016/j.arr.2024.102388 · Ageing research reviews · 2024 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | APOE | “Being age-related disorders, both Alzheimer's disease (AD) and stroke share multiple risk factors, such as hypertension, smoking, diabetes, and apolipoprotein E (APOE) Ɛ4 genotype, and coexist in patients.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Being age-related disorders, both Alzheimer's disease (AD) and stroke share multiple risk factors, such as hypertension, smoking, diabetes, and apolipoprotein E (APOE) Ɛ4 genotype, and coexist in patients.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | stroke | “The link between Alzheimer's disease and stroke: A detrimental synergism.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | hypertension | “Being age-related disorders, both Alzheimer's disease (AD) and stroke share multiple risk factors, such as hypertension, smoking, diabetes, and apolipoprotein E (APOE) Ɛ4 genotype, and coexist in patients.” | 0.98 | phenotype_alias_lexicon_v2 |
Apolipoprotein E Gene Variation in Pakistani Subjects with Type 2 Diabetes with and without Cardiovascular Complications.
PMID 38929578 | PMCID PMC11205396 | DOI 10.3390/medicina60060961 · Medicina (Kaunas, Lithuania) · 2024 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | APOE | “Background: Apolipoprotein E (APOE) gene polymorphism has been implicated in the pathogenesis of various metabolic disorders, including type 2 diabetes mellitus (T2DM).” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Apolipoprotein E Gene Variation in Pakistani Subjects with Type 2 Diabetes with and without Cardiovascular Complications.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | stroke | “The goal of this study is to investigate the relationship between Apolipoprotein E (ApoE) genotypes, dyslipidemia, and cardiovascular complications such as ischemic heart disease (IHD) and stroke.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | dyslipidemia | “The goal of this study is to investigate the relationship between Apolipoprotein E (ApoE) genotypes, dyslipidemia, and cardiovascular complications such as ischemic heart disease (IHD) and stroke.” | 0.98 | phenotype_alias_lexicon_v2 |
A Comprehensive Analysis of Unique and Recurrent Copy Number Variations in Alzheimer's Disease and its Related Disorders.
PMID 33256577 | DOI 10.2174/1567205017666201130111424 · Current Alzheimer research · 2020 · 17 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | APOE | “OBJECTIVE: We aimed to assess CNVs regions that may harbor genes contributing to AD, T2DM, and MDD in 67 Saudi familial and sporadic AD patients, with no alterations in the known genes of AD and genotyped previously for APOE.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Type 2 diabetes mellitus (T2DM) and major depressive disorder (MDD) were shown to have share mechanisms and signaling pathways with AD.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | AGRN | “We identified CNVs in genes that encode proteins involved in the metabolism of amyloid-β peptide (AGRN, APBA2, CR1, CR2, IGF2R, KIAA0125, MBP, RER1, RTN4R, VDR and WISPI) or Tau proteins (CACNAIC, CELF2, DUSP22, HTRA1 and SLC2A14).” | 0.98 | hgnc_dict_v1 |
| gene | APBA2 | “We identified CNVs in genes that encode proteins involved in the metabolism of amyloid-β peptide (AGRN, APBA2, CR1, CR2, IGF2R, KIAA0125, MBP, RER1, RTN4R, VDR and WISPI) or Tau proteins (CACNAIC, CELF2, DUSP22, HTRA1 and SLC2A14).” | 0.98 | hgnc_dict_v1 |
Association of Apolipoprotein E Polymorphism with Impact on Overweight University Pupils.
PMID 28085496 | DOI 10.1089/gtmb.2016.0190 · Genetic testing and molecular biomarkers · 2017 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | APOE | “Previous studies have revealed that obesity is associated with genetic variations including those found in the apolipoprotein E (APOE) gene, which also affects lipid profiles.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Patients with obesity tend to develop cardiovascular disease and type 2 diabetes.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | obesity | “Association of Apolipoprotein E Polymorphism with Impact on Overweight University Pupils.” | 0.93 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Hence, in this study, we aimed to perform a molecular characterization of APOE gene polymorphisms found in overweight subjects within a Saudi population. METHODS: A case-control study was performed consisting of 198 cases and 198 controls, selected from participants at the King Saud University. RESULTS: The present study identified the E4 allele of the APOE gene as being significantly associated with obesity in the Saudi population (p = 0.0001). CONCLUSION: Our results confirm that APOE variants are associated with obesity in the Saudi population.” | 0.95 | saudi_context_rules_v1 |