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APOE and hypertension are reported together in 2 articles.
Gene
APOE
- HGNC
- HGNC:613
46articles
46mentions
6variants with confirmed gene link
Most co-reported phenotypes (articles)
Alzheimer disease 18diabetes mellitus 6Parkinson disease 5dyslipidemia 5coronary artery disease 3stroke 3amyotrophic lateral sclerosis 2familial hypercholesterolemia 2
Reported variants (articles · ClinVar status)
Phenotype
Hypertension
828articles
828mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60The link between Alzheimer's disease and stroke: A detrimental synergism.
PMID 38914265 | DOI 10.1016/j.arr.2024.102388 · Ageing research reviews · 2024 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | APOE | “Being age-related disorders, both Alzheimer's disease (AD) and stroke share multiple risk factors, such as hypertension, smoking, diabetes, and apolipoprotein E (APOE) Ɛ4 genotype, and coexist in patients.” | 0.98 | hgnc_dict_v1 |
| phenotype | hypertension | “Being age-related disorders, both Alzheimer's disease (AD) and stroke share multiple risk factors, such as hypertension, smoking, diabetes, and apolipoprotein E (APOE) Ɛ4 genotype, and coexist in patients.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | stroke | “The link between Alzheimer's disease and stroke: A detrimental synergism.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | Alzheimer disease | “The link between Alzheimer's disease and stroke: A detrimental synergism.” | 0.93 | phenotype_alias_lexicon_v2 |
Apolipoprotein E Gene Variation in Pakistani Subjects with Type 2 Diabetes with and without Cardiovascular Complications.
PMID 38929578 | PMCID PMC11205396 | DOI 10.3390/medicina60060961 · Medicina (Kaunas, Lithuania) · 2024 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | APOE | “Background: Apolipoprotein E (APOE) gene polymorphism has been implicated in the pathogenesis of various metabolic disorders, including type 2 diabetes mellitus (T2DM).” | 0.98 | hgnc_dict_v1 |
| phenotype | hypertension | “Anthropometric parameters (age, BMI) and risk factors (smoking, diabetes duration, hypertension) were assessed in all groups.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | stroke | “The goal of this study is to investigate the relationship between Apolipoprotein E (ApoE) genotypes, dyslipidemia, and cardiovascular complications such as ischemic heart disease (IHD) and stroke.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | dyslipidemia | “The goal of this study is to investigate the relationship between Apolipoprotein E (ApoE) genotypes, dyslipidemia, and cardiovascular complications such as ischemic heart disease (IHD) and stroke.” | 0.98 | phenotype_alias_lexicon_v2 |