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APOE and obesity are reported together in 1 article.
Gene
APOE
- HGNC
- HGNC:613
46articles
46mentions
6variants with confirmed gene link
Most co-reported phenotypes (articles)
Alzheimer disease 18diabetes mellitus 6Parkinson disease 5dyslipidemia 5coronary artery disease 3stroke 3amyotrophic lateral sclerosis 2familial hypercholesterolemia 2
Reported variants (articles · ClinVar status)
Phenotype
Obesity
- HPO
- HP:0001513
856articles
856mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Association of Apolipoprotein E Polymorphism with Impact on Overweight University Pupils.
PMID 28085496 | DOI 10.1089/gtmb.2016.0190 · Genetic testing and molecular biomarkers · 2017 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | APOE | “Previous studies have revealed that obesity is associated with genetic variations including those found in the apolipoprotein E (APOE) gene, which also affects lipid profiles.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “Association of Apolipoprotein E Polymorphism with Impact on Overweight University Pupils.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | diabetes mellitus | “Patients with obesity tend to develop cardiovascular disease and type 2 diabetes.” | 0.93 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Hence, in this study, we aimed to perform a molecular characterization of APOE gene polymorphisms found in overweight subjects within a Saudi population. METHODS: A case-control study was performed consisting of 198 cases and 198 controls, selected from participants at the King Saud University. RESULTS: The present study identified the E4 allele of the APOE gene as being significantly associated with obesity in the Saudi population (p = 0.0001). CONCLUSION: Our results confirm that APOE variants are associated with obesity in the Saudi population.” | 0.95 | saudi_context_rules_v1 |