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AURKA and hepatocellular carcinoma are reported together in 4 articles.
Gene
AURKA
- HGNC
- HGNC:11393
16articles
16mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Hepatocellular carcinoma
417articles
417mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
4 records shown · first 60Identification of potential key genes and molecular mechanisms of oral squamous cell carcinoma based on integrated bioinformatics approach.
PMID 41839689 | PMCID PMC12994033 | DOI 10.1016/j.jgeb.2026.100668 · Journal, genetic engineering & biotechnology · 2026 · 10 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | AURKA | “The hub genes are Kinesin Family Member 23 (KIF23), Aurora Kinase A (AURKA), Centromere Protein F (CENPF), Cell Division Cycle 20 (CDC20), Discs Large Associated Protein 5 (DLGAP5), Centrosomal Protein 55 (CEP55), Anillin Actin Binding Protein (ANLN), Non-SMC Condensin I Complex Subunit G (NCAPG), and Kinesin Family Member 14 (KIF14).” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “Previous study shows KIF23 takes part in raising Cell Proliferation in Hepatocellular carcinoma cells and AURKA shows notable overexpression in cancer tissues, which indicates that KIF23 and AURKA showed promising character to become possible biomarkers for OSCC.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | KIF23 | “The hub genes are Kinesin Family Member 23 (KIF23), Aurora Kinase A (AURKA), Centromere Protein F (CENPF), Cell Division Cycle 20 (CDC20), Discs Large Associated Protein 5 (DLGAP5), Centrosomal Protein 55 (CEP55), Anillin Actin Binding Protein (ANLN), Non-SMC Condensin I Complex Subunit G (NCAPG), and Kinesin Family Member 14 (KIF14).” | 0.98 | hgnc_dict_v1 |
| gene | CENPF | “The hub genes are Kinesin Family Member 23 (KIF23), Aurora Kinase A (AURKA), Centromere Protein F (CENPF), Cell Division Cycle 20 (CDC20), Discs Large Associated Protein 5 (DLGAP5), Centrosomal Protein 55 (CEP55), Anillin Actin Binding Protein (ANLN), Non-SMC Condensin I Complex Subunit G (NCAPG), and Kinesin Family Member 14 (KIF14).” | 0.98 | hgnc_dict_v1 |
An Integrated Framework to Identify Prognostic Biomarkers and Novel Therapeutic Targets in Hepatocellular Carcinoma-Based Disabilities.
PMID 39765633 | PMCID PMC11673266 | DOI 10.3390/biology13120966 · Biology · 2024 · 15 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | AURKA | “Survival analyses indicated that 11 hub genes (CCNB1, AURKA, RACGAP1, CEP55, SMC4, RRM2, PRC1, CKAP2, SMC2, UHRF1, and FANCI) and three transcription factors (E2F1, CREB1, and NFYA) are strongly linked to poor patient survival.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors globally, significantly affecting liver functions, thus necessitating the identification of biomarkers and effective therapeutics to improve HCC-based disabilities.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CCNB1 | “Survival analyses indicated that 11 hub genes (CCNB1, AURKA, RACGAP1, CEP55, SMC4, RRM2, PRC1, CKAP2, SMC2, UHRF1, and FANCI) and three transcription factors (E2F1, CREB1, and NFYA) are strongly linked to poor patient survival.” | 0.98 | hgnc_dict_v1 |
| gene | RACGAP1 | “Survival analyses indicated that 11 hub genes (CCNB1, AURKA, RACGAP1, CEP55, SMC4, RRM2, PRC1, CKAP2, SMC2, UHRF1, and FANCI) and three transcription factors (E2F1, CREB1, and NFYA) are strongly linked to poor patient survival.” | 0.98 | hgnc_dict_v1 |
Exploring potential key genes and pathways associatedwith hepatocellular carcinoma prognosis through bioinformatics analysis, followed by experimental validation.
PMID 39822558 | PMCID PMC11733333 | DOI 10.62347/WIER4743 · American journal of translational research · 2024 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | AURKA | “Finally, AURKA was knocked down in HepG2 cells, and cell proliferation, colony formation, and wound healing assays were performed.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “Exploring potential key genes and pathways associatedwith hepatocellular carcinoma prognosis through bioinformatics analysis, followed by experimental validation.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | BUB1B | “RESULTS: Analysis identified 180 DEGs, with four key hub genes, including AURKA, BUB1B, CCNA2, and PTTG1 showing significant overexpression and hypomethylation in LIHC tissues.” | 0.98 | hgnc_dict_v1 |
| gene | CCNA2 | “RESULTS: Analysis identified 180 DEGs, with four key hub genes, including AURKA, BUB1B, CCNA2, and PTTG1 showing significant overexpression and hypomethylation in LIHC tissues.” | 0.98 | hgnc_dict_v1 |
Identifying key genes and screening therapeutic agents associated with diabetes mellitus and HCV-related hepatocellular carcinoma by bioinformatics analysis.
PMID 34588861 | PMCID PMC8459114 | DOI 10.1016/j.sjbs.2021.07.068 · Saudi journal of biological sciences · 2021 · 13 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | AURKA | “PPI network obtained from STRING were subjected to Cytoscape plugin cytoHubba, and top 10 genes (AURKA, JUN, AR, MELK, NCOA2, CENPF, NCAPG, PCK1, RAD51AP1, and GTSE1) were chosen as the target hub genes based on the highest degree of connectivity.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “Identifying key genes and screening therapeutic agents associated with diabetes mellitus and HCV-related hepatocellular carcinoma by bioinformatics analysis.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | JUN | “PPI network obtained from STRING were subjected to Cytoscape plugin cytoHubba, and top 10 genes (AURKA, JUN, AR, MELK, NCOA2, CENPF, NCAPG, PCK1, RAD51AP1, and GTSE1) were chosen as the target hub genes based on the highest degree of connectivity.” | 0.98 | hgnc_dict_v1 |
| gene | AR | “PPI network obtained from STRING were subjected to Cytoscape plugin cytoHubba, and top 10 genes (AURKA, JUN, AR, MELK, NCOA2, CENPF, NCAPG, PCK1, RAD51AP1, and GTSE1) were chosen as the target hub genes based on the highest degree of connectivity.” | 0.98 | hgnc_dict_v1 |