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BAX and Alzheimer disease are reported together in 1 article.
Gene
BAX
- HGNC
- HGNC:959
150articles
150mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 25colorectal cancer 15hepatocellular carcinoma 10lymphoma 10lung cancer 9ulcerative colitis 4inflammatory bowel disease 3leukemia 3
Reported variants (articles · ClinVar status)
Phenotype
Alzheimer disease
455articles
455mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies.
PMID 39830909 | PMCID PMC11742186 | DOI 10.1002/fsn3.4682 · Food science & nutrition · 2025 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “By Increasing BAX protein expression; decreasing VEGF and Bcl-2 expression it can initiate cell cycle arrest and apoptosis.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “This review is an attempt to elaborate molecular targets of luteolin and its role in modulating irregularities in cellular pathways to overcome severe outcomes during diseases including cancer, cardiovascular disorders, diabetes, obesity, inflammation, Alzheimer's disease, Parkinson's disease, hepatic disorders, renal disorders, brain injury, and asthma.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CDK2 | “Luteolin prevents cancer via modulation of numerous pathways, that is, by inactivating proteins; such as procaspase-9, CDC2 and cyclin B or upregulation of caspase-9 and caspase-3, cytochrome C, cyclin A, CDK2, and APAF-1, in turn inducing cell cycle arrest as well as apoptosis.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “This review is an attempt to elaborate molecular targets of luteolin and its role in modulating irregularities in cellular pathways to overcome severe outcomes during diseases including cancer, cardiovascular disorders, diabetes, obesity, inflammation, Alzheimer's disease, Parkinson's disease, hepatic disorders, renal disorders, brain injury, and asthma.” | 0.98 | phenotype_alias_lexicon_v2 |