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BAX and breast cancer are reported together in 25 articles.
Gene
BAX
- HGNC
- HGNC:959
150articles
150mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 25colorectal cancer 15hepatocellular carcinoma 10lymphoma 10lung cancer 9ulcerative colitis 4inflammatory bowel disease 3leukemia 3
Reported variants (articles · ClinVar status)
Phenotype
Breast cancer
1,211articles
1,211mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
25 records shown · first 60Structural reprogramming of irradiated ellagic acid suppresses cell cycle regulators and modulates cytokines via activation of the p53/BAX-CASP3/Bcl-2-cyclin D1 pathway: Validation studies across breast cancer cell lines.
PMID 41679479 | DOI 10.1016/j.ijbiomac.2026.150821 · International journal of biological macromolecules · 2026 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “Protein expression validation was performed using immunofluorescence microscopy and qRT-PCR analysis targeting key apoptotic genes (p53, BAX, BCL-2, CASP3, Cyclin D1).” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Structural reprogramming of irradiated ellagic acid suppresses cell cycle regulators and modulates cytokines via activation of the p53/BAX-CASP3/Bcl-2-cyclin D1 pathway: Validation studies across breast cancer cell lines.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CASP3 | “Protein expression validation was performed using immunofluorescence microscopy and qRT-PCR analysis targeting key apoptotic genes (p53, BAX, BCL-2, CASP3, Cyclin D1).” | 0.98 | hgnc_dict_v1 |
Marine Klebsiella sp. RR1-mediated AgNPs functionalized with matcha: synthesis, characterization, and evaluation of antibacterial, antioxidant, anti-inflammatory, and gene regulation of breast cancer potentials.
PMID 41832508 | PMCID PMC13101116 | DOI 10.1186/s12934-026-02981-4 · Microbial cell factories · 2026 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “By repressing the anti-apoptotic BCL-2 gene and increasing the pro-apoptotic BAX gene, the two therapies mechanistically produced cell death.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “RR1-mediated AgNPs functionalized with matcha: synthesis, characterization, and evaluation of antibacterial, antioxidant, anti-inflammatory, and gene regulation of breast cancer potentials.” | 0.98 | phenotype_alias_lexicon_v2 |
PD-L1 targeting in triple negative breast cancer: in silico and in vitro validation of wasp venom peptide MP-1.
PMID 41284169 | DOI 10.1007/s12032-025-03133-1 · Medical oncology (Northwood, London, England) · 2025 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “Gene expression studies showed significant down regulation of PD-L1, EGFR, STAT3, BCL2 and Ki-67, while the up regulation of Caspase-3, Caspase-9 and BAX (p < 0.0001).” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “PD-L1 targeting in triple negative breast cancer: in silico and in vitro validation of wasp venom peptide MP-1.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | EGFR | “Gene expression studies showed significant down regulation of PD-L1, EGFR, STAT3, BCL2 and Ki-67, while the up regulation of Caspase-3, Caspase-9 and BAX (p < 0.0001).” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Gene expression studies showed significant down regulation of PD-L1, EGFR, STAT3, BCL2 and Ki-67, while the up regulation of Caspase-3, Caspase-9 and BAX (p < 0.0001).” | 0.98 | hgnc_dict_v1 |
Novel triazoloquinazoline derivatives as VEGFR inhibitors: synthesis, cytotoxic evaluation and in silico studies.
PMID 39995350 | PMCID PMC11901504 | DOI 10.1080/17568919.2025.2468146 · Future medicinal chemistry · 2025 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “It significantly inhibited VEGFR-2 and altered gene expression, promoting BAX, P21, and P53 while downregulating BCL-2.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “RESEARCH DESIGN AND METHODS: All synthesized compounds were confirmed by spectroscopic methods and tested in vitro for their inhibitory activities against hepatocellular carcinoma (HepG-2), breast cancer (MCF-7), and prostate cancer (PC3) cell lines.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | prostate cancer | “RESEARCH DESIGN AND METHODS: All synthesized compounds were confirmed by spectroscopic methods and tested in vitro for their inhibitory activities against hepatocellular carcinoma (HepG-2), breast cancer (MCF-7), and prostate cancer (PC3) cell lines.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | hepatocellular carcinoma | “RESEARCH DESIGN AND METHODS: All synthesized compounds were confirmed by spectroscopic methods and tested in vitro for their inhibitory activities against hepatocellular carcinoma (HepG-2), breast cancer (MCF-7), and prostate cancer (PC3) cell lines.” | 0.98 | phenotype_alias_lexicon_v2 |
Rosemary reduced estrogen receptor (ESR1) protein mediated cycle arrest and apoptosis: A potential hormonal dependent anticancer mechanism of the plant in the MCF-7 breast cancer cells.
PMID 40761051 | DOI 10.36721/PJPS.2025.38.4.REG.13514.1 · Pakistan journal of pharmaceutical sciences · 2025 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “The downregulation of ESR1 led to G0/G1 cell cycle arrest and apoptosis through the activation of downstream pathways, resulting in increased expression of TP53 and BAX, while reducing Bcl2 levels, ultimately leading to apoptosis.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Rosemary reduced estrogen receptor (ESR1) protein mediated cycle arrest and apoptosis: A potential hormonal dependent anticancer mechanism of the plant in the MCF-7 breast cancer cells.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | ESR1 | “Rosemary reduced estrogen receptor (ESR1) protein mediated cycle arrest and apoptosis: A potential hormonal dependent anticancer mechanism of the plant in the MCF-7 breast cancer cells.” | 0.98 | hgnc_dict_v1 |
| gene | TP53 | “The downregulation of ESR1 led to G0/G1 cell cycle arrest and apoptosis through the activation of downstream pathways, resulting in increased expression of TP53 and BAX, while reducing Bcl2 levels, ultimately leading to apoptosis.” | 0.98 | hgnc_dict_v1 |
Development of new anticancer thiadiazole-sulfonamides as dual EGFR/carbonic anhydrase inhibitors.
PMID 40337848 | PMCID PMC12091935 | DOI 10.1080/17568919.2025.2498879 · Future medicinal chemistry · 2025 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “Apoptosis was assessed through gene expression analysis of BAX/Bcl-2, caspase-8, and caspase-9, alongside flow cytometry for apoptosis and cell cycle analysis.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “METHODS: Cytotoxicity was evaluated against MDA-MB-231 and MCF-7 breast cancer cells, with selectivity tested on Vero cells.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | EGFR | “Development of new anticancer thiadiazole-sulfonamides as dual EGFR/carbonic anhydrase inhibitors.” | 0.98 | hgnc_dict_v1 |
Exploring the Cytotoxic and Redox-Modulatory Effects of Nanoceria in MCF7 Breast Cancer Cells Using Integrated Molecular and Proteomic Analyses.
PMID 41300519 | PMCID PMC12649274 | DOI 10.3390/antiox14111361 · Antioxidants (Basel, Switzerland) · 2025 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “Gene expression analysis supported activation of apoptotic pathways demonstrated by upregulation of BNIP3, the BAX/BCL-2 ratio (p < 0.05), and disruption of mitochondrial homeostasis.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Exploring the Cytotoxic and Redox-Modulatory Effects of Nanoceria in MCF7 Breast Cancer Cells Using Integrated Molecular and Proteomic Analyses.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | BNIP3 | “Gene expression analysis supported activation of apoptotic pathways demonstrated by upregulation of BNIP3, the BAX/BCL-2 ratio (p < 0.05), and disruption of mitochondrial homeostasis.” | 0.98 | hgnc_dict_v1 |
Development of New Thiadiazole Derivatives as VEGFR-2 Inhibitors With Anticancer and Proapoptotic Activities.
PMID 40590181 | DOI 10.1002/ardp.70042 · Archiv der Pharmazie · 2025 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “Treatment with 7b increased the expression of the proapoptotic gene BAX (4.19 ± 0.34-fold) and suppressed the expression of the antiapoptotic gene Bcl-2 (0.38 ± 0.02-fold), resulting in a dramatic increase in the BAX/Bcl-2 ratio (11.03 ± 1.66-fold).” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Among them, compound 7b demonstrated significant cytotoxic activity against MCF-7 breast cancer cells, with an IC50 value of 6.13 µM, surpassing that of the reference drug sorafenib (IC50: 7.26 µM).” | 0.98 | phenotype_alias_lexicon_v2 |
New 1,3,4-Thiadiazole-Based Dual B-Raf/VEGFR-2 Inhibitors With Potential Anti-Breast Activity: Design, Synthesis, In Vitro and In Silico Evaluations.
PMID 41017166 | DOI 10.1002/ardp.70097 · Archiv der Pharmazie · 2025 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “Flow cytometry and gene expression analysis revealed that 7b induces G1-phase cell-cycle arrest and promotes apoptosis through the upregulation of BAX, caspases-8/9, and downregulation of Bcl-2.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Among the synthesized compounds, 7b emerged as the most potent candidate, exhibiting strong cytotoxicity against the MDA-MB-231 and MCF-7 breast cancer cell lines (IC₅₀ = 9.66 and 15.83 µM, respectively), with minimal toxicity toward normal WI-38 and WISH cells, reflected by favorable selectivity indices.” | 0.98 | phenotype_alias_lexicon_v2 |
Extraction, LC-QTOF-MS profiling of bacterial menaquinone (MK) and characterization of CuFe2O4 nanoparticles loaded MK: potential anti-cancer via gene expression.
PMID 41353281 | PMCID PMC12789059 | DOI 10.1038/s41598-025-30886-6 · Scientific reports · 2025 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “CuFe2O4 NPs modified with MK exhibited significant cytotoxicity against MCF-7 cells, yielding an IC₅₀ of 48.94 µg/ml and a notable 45% reduction in BCL-2 expression, while BAX expression experienced a marginal 3.4% rise.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “This study demonstrates its strength in innovative design and comprehensive characterization of a novel anti-cancer nanocomposite (CuFe₂O₄ NPs-MK), utilizing sustainably sourced marine MKs to induce apoptosis in breast cancer cells by modulating the BAX/BCL-2 gene ratio.” | 0.98 | phenotype_alias_lexicon_v2 |
Achillea fragrantissima (Forssk.) Sch.Bip instigates the ROS/FADD/c-PARP expression that triggers apoptosis in breast cancer cell (MCF-7).
PMID 38820323 | PMCID PMC11142488 | DOI 10.1371/journal.pone.0304072 · PloS one · 2024 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “In addition, the qRT-PCR technique authenticates the A. fragrantissima -induced apoptotic network genes (Caspase-3, Caspase-8, Caspase-9, Cytochrome c, BCL-2, BID, BAX, PARP, PTEN, PI3K, and Akt) expression were evaluated.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Achillea fragrantissima (Forssk.) Sch.Bip instigates the ROS/FADD/c-PARP expression that triggers apoptosis in breast cancer cell (MCF-7).” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | FADD | “Achillea fragrantissima (Forssk.) Sch.Bip instigates the ROS/FADD/c-PARP expression that triggers apoptosis in breast cancer cell (MCF-7).” | 0.98 | hgnc_dict_v1 |
| gene | BID | “In addition, the qRT-PCR technique authenticates the A. fragrantissima -induced apoptotic network genes (Caspase-3, Caspase-8, Caspase-9, Cytochrome c, BCL-2, BID, BAX, PARP, PTEN, PI3K, and Akt) expression were evaluated.” | 0.98 | hgnc_dict_v1 |
Studying the effects of secondary metabolites isolated from Cycas thouarsii R.Br. leaves on MDA-MB-231 breast cancer cells.
PMID 38279824 | DOI 10.1080/21691401.2024.2306529 · Artificial cells, nanomedicine, and biotechnology · 2024 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “An upregulation of the pro-apoptotic genes (BAX and P53) and a downregulation of the anti-apoptotic gene (BCL-2) were observed.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Studying the effects of secondary metabolites isolated from Cycas thouarsii R.Br. leaves on MDA-MB-231 breast cancer cells.” | 0.98 | phenotype_alias_lexicon_v2 |
Design, synthesis, molecular docking, and in vitro studies of 2-mercaptoquinazolin-4(3H)-ones as potential anti-breast cancer agents.
PMID 38357701 | PMCID PMC10864842 | DOI 10.1016/j.jsps.2024.101971 · Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “The relative gene expression of pro-apoptotic and anti-apoptotic genes revealed an overexpression of the P53 and BAX genes and a downregulation of the BCL-2 gene by real-time PCR.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Triple-negative breast cancer (TNBC) comprises 10 % to 20 % of breast cancer, however, it is more dangerous than other types of breast cancer, because it lacks druggable targets, such as the estrogen receptors (ER) and the progesterone receptor (PR), and has under expressed receptor tyrosine kinase, ErbB2.” | 0.98 | phenotype_alias_lexicon_v2 |
Evaluation of the anticancer activity of Origanum Marjoram as a safe natural drink for daily use.
PMID 37688795 | DOI 10.1080/03639045.2023.2257796 · Drug development and industrial pharmacy · 2023 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “Also, OMAE showed a modification in bcl-2, tumor suppressor gene (p53), and Bax levels and influenced the BAX/BCL-2 ratio via releasing the cytochrome C.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “CONCLUSION: The results of the study were promising, suggesting that the reduced apoptotic rate of MCF-7 breast cancer cells in this work was correlated to the potential anticancer effect of OMAE which would be a suitable preventable drink against cancer.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | ESR1 | “Moreover, quantitative real-time PCR (qRT-PCR) was used to detect specific genes associated with cancer, such as ESR1, Bax, Bcl-2, and p53.” | 0.98 | hgnc_dict_v1 |
Reinvestigation of Passerini and Ugi scaffolds as multistep apoptotic inducers via dual modulation of caspase 3/7 and P53-MDM2 signaling for halting breast cancer.
PMID 37736568 | PMCID PMC10509784 | DOI 10.1039/d3ra04029a · RSC advances · 2023 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “Further apoptosis studies revealed that these compounds enhanced gene expression of BAX by 2 folds and suppressed Bcl-2 expression by 4.29-7.75 folds in the treated MCF-7 cells.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Reinvestigation of Passerini and Ugi scaffolds as multistep apoptotic inducers via dual modulation of caspase 3/7 and P53-MDM2 signaling for halting breast cancer.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | MDM2 | “The adopted design rationale and synthetic routes relied on mimicking the general thematic features of lead MDM2 inhibitors incorporating multiple aromatic rings.” | 0.98 | hgnc_dict_v1 |
Anticancer and anti-metastasis activity of 1,25 dihydroxycholecalciferols and genistein in MCF-7 and MDA-MB-231 breast cancer cell lines.
PMID 38034665 | PMCID PMC10682641 | DOI 10.1016/j.heliyon.2023.e21975 · Heliyon · 2023 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “Stimulation of apoptosis was achieved by upregulating the expression of BAX and CASP3 genes and downregulating the expression levels of BCL-2 gene.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Anticancer and anti-metastasis activity of 1,25 dihydroxycholecalciferols and genistein in MCF-7 and MDA-MB-231 breast cancer cell lines.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CASP3 | “Stimulation of apoptosis was achieved by upregulating the expression of BAX and CASP3 genes and downregulating the expression levels of BCL-2 gene.” | 0.98 | hgnc_dict_v1 |
Investigation of the Anticancer Effect of α-Aminophosphonates and Arylidine Derivatives of 3-Acetyl-1-aminoquinolin-2(1H)-one on the DMBA Model of Breast Cancer in Albino Rats with In Silico Prediction of Their Thymidylate Synthase Inhibitory Effect.
PMID 35164019 | PMCID PMC8839308 | DOI 10.3390/molecules27030756 · Molecules (Basel, Switzerland) · 2022 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “Gene expression of GST-P, PCNA, PDK, and PIK3CA decreased in the DMBA group treated with α-aminophosphonates and arylidine derivatives of 3-acetyl-1-aminoquinolin-2(1H)-one, whereas PIK3R1 and BAX increased in the DMBA group treated with α-aminophosphonates and arylidine derivatives of 3-acetyl-1-aminoquinolin-2(1H)-one.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Investigation of the Anticancer Effect of α-Aminophosphonates and Arylidine Derivatives of 3-Acetyl-1-aminoquinolin-2(1H)-one on the DMBA Model of Breast Cancer in Albino Rats with In Silico Prediction of Their Thymidylate Synthase Inhibitory Effect.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | PCNA | “Gene expression of GST-P, PCNA, PDK, and PIK3CA decreased in the DMBA group treated with α-aminophosphonates and arylidine derivatives of 3-acetyl-1-aminoquinolin-2(1H)-one, whereas PIK3R1 and BAX increased in the DMBA group treated with α-aminophosphonates and arylidine derivatives of 3-acetyl-1-aminoquinolin-2(1H)-one.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Gene expression of GST-P, PCNA, PDK, and PIK3CA decreased in the DMBA group treated with α-aminophosphonates and arylidine derivatives of 3-acetyl-1-aminoquinolin-2(1H)-one, whereas PIK3R1 and BAX increased in the DMBA group treated with α-aminophosphonates and arylidine derivatives of 3-acetyl-1-aminoquinolin-2(1H)-one.” | 0.98 | hgnc_dict_v1 |
New Series of VEGFR-2 Inhibitors and Apoptosis Enhancers: Design, Synthesis and Biological Evaluation.
PMID 35281317 | PMCID PMC8904266 | DOI 10.2147/DDDT.S344750 · Drug design, development and therapy · 2022 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “Moreover, compound 11 raised the apoptosis rate in HepG-2 cells from 5% to 44% and caused 4, 2.3, and 3-fold increases in BAX/Bcl-2 ratio, caspase-3 level, and P53 expression, respectively, compared to control untreated cells.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “METHODS: The new candidates were evaluated against A549 lung cancer cells, HepG-2 hepatoma cells, Caco-2 colon cancer cells, MDA breast cancer cells, and VEGFR-2 kinase.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | lung cancer | “METHODS: The new candidates were evaluated against A549 lung cancer cells, HepG-2 hepatoma cells, Caco-2 colon cancer cells, MDA breast cancer cells, and VEGFR-2 kinase.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | colorectal cancer | “METHODS: The new candidates were evaluated against A549 lung cancer cells, HepG-2 hepatoma cells, Caco-2 colon cancer cells, MDA breast cancer cells, and VEGFR-2 kinase.” | 0.93 | phenotype_alias_lexicon_v2 |
Pharmacophore-based virtual screening approaches to identify novel molecular candidates against EGFR through comprehensive computational approaches and in-vitro studies.
PMID 36457709 | PMCID PMC9707641 | DOI 10.3389/fphar.2022.1027890 · Frontiers in pharmacology · 2022 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “MTT assay, gene expression analysis (BAX, BCL-2, and β-catenin), apoptosis analysis, TEM, cell cycle assay, ELISA, and cell migration assays were conducted to perform the cell death analysis of lung cancer and breast cancer, compared to the marketed product.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “MTT assay, gene expression analysis (BAX, BCL-2, and β-catenin), apoptosis analysis, TEM, cell cycle assay, ELISA, and cell migration assays were conducted to perform the cell death analysis of lung cancer and breast cancer, compared to the marketed product.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | EGFR | “Pharmacophore-based virtual screening approaches to identify novel molecular candidates against EGFR through comprehensive computational approaches and in-vitro studies.” | 0.98 | hgnc_dict_v1 |
| phenotype | lung cancer | “Alterations to the EGFR (epidermal growth factor receptor) gene, which primarily occur in the axon 18-21 position, have been linked to a variety of cancers, including ovarian, breast, colon, and lung cancer.” | 0.98 | phenotype_alias_lexicon_v2 |
BCL-2 (-938C>A), BAX (-248G>A), and HER2 Ile655Val Polymorphisms and Breast Cancer Risk in Indian Population.
PMID 33708254 | PMCID PMC7932784 | DOI 10.1155/2021/8865624 · Journal of oncology · 2021 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “BCL-2 (-938C>A), BAX (-248G>A), and HER2 Ile655Val Polymorphisms and Breast Cancer Risk in Indian Population.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “BCL-2 (-938C>A), BAX (-248G>A), and HER2 Ile655Val Polymorphisms and Breast Cancer Risk in Indian Population.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | -938C>A | “BCL-2 (-938C>A), BAX (-248G>A), and HER2 Ile655Val Polymorphisms and Breast Cancer Risk in Indian Population.” | 0.82 | literature_variant_regex_v2 |
| variant | -248G>A | “BCL-2 (-938C>A), BAX (-248G>A), and HER2 Ile655Val Polymorphisms and Breast Cancer Risk in Indian Population.” | 0.82 | literature_variant_regex_v2 |
BCL-2 Inhibitor Venetoclax Induces Autophagy-Associated Cell Death, Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells.
PMID 33414642 | PMCID PMC7783200 | DOI 10.2147/OTT.S281519 · OncoTargets and therapy · 2020 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “This effect was associated with a significant increase in the percentage of apoptotic MDA-MB-231 cells and in the expression of the apoptotic genes, caspase 3, caspase 7, and BAX, with inhibition of anti-apoptotic gene, BCL-2 levels.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “BCL-2 Inhibitor Venetoclax Induces Autophagy-Associated Cell Death, Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | E2F1 | “Induction of apoptosis by VCX treatment induced cell cycle arrest at G0/G1 phase with inhibition of cell proliferator genes, cyclin D1 and E2F1.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “INTRODUCTION: Venetoclax (VCX) is a selective BCL-2 inhibitor approved for the treatment of leukemia and lymphoma.” | 0.98 | phenotype_alias_lexicon_v2 |
Cucurbita ficifolia Fruit Extract Induces Tp53/Caspase-Mediated Apoptosis in MCF-7 Breast Cancer Cells.
PMID 32685475 | PMCID PMC7335397 | DOI 10.1155/2020/3712536 · BioMed research international · 2020 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “Further, we observed that C. ficifolia extract-induced programmed cell death in the MCF-7 cells were mediated with the elevated expression of the tumor suppressor gene such as p53 and apoptotic markers such as caspase-8, caspase-9, caspase-3, fatty acid synthase (FAS), Fas-associated protein with death domain (FADD), Bcl-2 homologous antagonist/killer (BAK), and Bcl-2-associated X protein (BAX).” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Cucurbita ficifolia Fruit Extract Induces Tp53/Caspase-Mediated Apoptosis in MCF-7 Breast Cancer Cells.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | FAS | “Further, we observed that C. ficifolia extract-induced programmed cell death in the MCF-7 cells were mediated with the elevated expression of the tumor suppressor gene such as p53 and apoptotic markers such as caspase-8, caspase-9, caspase-3, fatty acid synthase (FAS), Fas-associated protein with death domain (FADD), Bcl-2 homologous antagonist/killer (BAK), and Bcl-2-associated X protein (BAX).” | 0.98 | hgnc_dict_v1 |
| gene | FADD | “Further, we observed that C. ficifolia extract-induced programmed cell death in the MCF-7 cells were mediated with the elevated expression of the tumor suppressor gene such as p53 and apoptotic markers such as caspase-8, caspase-9, caspase-3, fatty acid synthase (FAS), Fas-associated protein with death domain (FADD), Bcl-2 homologous antagonist/killer (BAK), and Bcl-2-associated X protein (BAX).” | 0.98 | hgnc_dict_v1 |
Biological Activity, Apoptotic Induction and Cell Cycle Arrest of New Hydrazonoyl Halides Derivatives.
PMID 30843494 | DOI 10.2174/1871520619666190306123658 · Anti-cancer agents in medicinal chemistry · 2019 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “Real time PCR analysis indicates that the two compounds induced the apoptosis of MCF7 cells through the up regulation of caspase-3, BAX mediated P53 mechanism but unfortunately, they promote the expression of anti-apoptotic protein BCL2.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Two biochemical tests were performed using the two halides 2c and 2f to predict their mechanism of action against breast carcinoma.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | BCL2 | “Real time PCR analysis indicates that the two compounds induced the apoptosis of MCF7 cells through the up regulation of caspase-3, BAX mediated P53 mechanism but unfortunately, they promote the expression of anti-apoptotic protein BCL2.” | 0.98 | hgnc_dict_v1 |
| phenotype | colorectal cancer | “Single dose test (100μg/ml) showed that, in case of PC3, all compounds have cytotoxic activity over 90% inhibition, 4 compounds have cytotoxic activity with 100% inhibition with Human colon cancer cell line, 4 compounds showed over 90% inhibition with MCF7 cell line and 4 compounds showed cytotoxic activity over 90% inhibition with HepG-2.” | 0.93 | phenotype_alias_lexicon_v2 |
Characterization of Apoptosis in a Breast Cancer Cell Line after IL-10 Silencing.
PMID 29582634 | PMCID PMC5980855 | DOI 10.22034/APJCP.2018.19.3.777 · Asian Pacific journal of cancer prevention : APJCP · 2018 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “IL-10 gene silencing causes down regulation of both PI3K/AKT and Bcl2 gene expression and also increases the Bbc3, BAX caspase3, and caspase 3 cleavage expression levels.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Characterization of Apoptosis in a Breast Cancer Cell Line after IL-10 Silencing.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | GAPDH | “Methods: The siRNA targeting IL-10 and a glyceraldehyde 3-phosphate dehydrogenase (GAPDH) clone were introduced into MDA-MB-231 cells.” | 0.98 | hgnc_dict_v1 |
| phenotype | lymphoma | “Real-time PCR assays were used to determine IL-10 and GAPDH gene expression levels, in addition to those for protein kinase B (AKT), phosphoinositide 3-kinase (PI3K), B-cell lymphoma 2 (Bcl2), caspase-3 and caspase-9 genes related to apoptosis.” | 0.98 | phenotype_alias_lexicon_v2 |
Isolation and characterization of three new anti-proliferative Sesquiterpenes from Polygonum barbatum and their mechanism via apoptotic pathway.
PMID 29061136 | PMCID PMC5654143 | DOI 10.1186/s12885-017-3667-9 · BMC cancer · 2017 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “It significantly downregulated, the expression of anti-apoptotic (BCL-2 L1 and p53) and increased the expression of pro-apoptotic (BAK and BAX) genes.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “RESULTS: All the compounds 1-3 were subjected to anti-proliferative potential against non-small cell lung carcinoma (NCI-H460), breast cancer (MCF-7), cervical cancer (HeLa) and normal mouse fibroblast (NIH-3 T3) cell lines.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | lung cancer | “Furthermore, the compounds 1-3 were subjected to screening of anti-cancer activity against different cell lines followed by brief analysis of apoptotic and anti-angiogenic potentials of the potent hit against non-small cell lung carcinoma cell line.” | 0.93 | phenotype_alias_lexicon_v2 |