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BAX and cardiomyopathy are reported together in 1 article.
Gene
BAX
- HGNC
- HGNC:959
150articles
150mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 25colorectal cancer 15hepatocellular carcinoma 10lymphoma 10lung cancer 9ulcerative colitis 4inflammatory bowel disease 3leukemia 3
Reported variants (articles · ClinVar status)
Phenotype
Cardiomyopathy
- HPO
- HP:0001638
618articles
618mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60LCZ696 Protects against Diabetic Cardiomyopathy-Induced Myocardial Inflammation, ER Stress, and Apoptosis through Inhibiting AGEs/NF-κB and PERK/CHOP Signaling Pathways.
PMID 35163209 | PMCID PMC8836005 | DOI 10.3390/ijms23031288 · International journal of molecular sciences · 2022 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BAX | “LCZ696 and valsartan ameliorated DCM progression by inhibiting AGEs formation at activity levels; pro-apoptotic markers (BAX/Bcl2 ratio and caspase-3) in mRNA and protein expressions, the NF-κB at mRNA; and protein levels associated with the restoration of elevated proinflammatory cytokines such as the TNF-α, IL-6, and IL-1β at the activity level.” | 0.98 | hgnc_dict_v1 |
| phenotype | cardiomyopathy | “The present study is designed to determine the effect of LCZ696 on DCM in rats and investigate the underlying mechanism involved.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | ATF4 | “Furthermore, LCZ696 and valsartan contribute to restoring the induction of ER stress parameters (GRP78, PERK, eIF2a, ATF4, and CHOP) at mRNA and protein levels.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Diabetes was induced by feeding rats with a high-fat diet for six weeks following a single injection of STZ (30 mg/kg).” | 0.93 | phenotype_alias_lexicon_v2 |