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BCL2 and lymphoma are reported together in 17 articles.
Gene
BCL2
- HGNC
- HGNC:990
105articles
105mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
lymphoma 17colorectal cancer 12breast cancer 10hepatocellular carcinoma 8ulcerative colitis 5Alzheimer disease 4leukemia 4diabetes mellitus 3
Reported variants (articles · ClinVar status)
Phenotype
Lymphoma
428articles
428mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
17 records shown · first 60Anti-inflammatory effect of pirfenidone compared to dexamethasone in ulcerative colitis model induced by acetic acid in rats: involvement of miR-146a and TLR4/NF-κB signaling.
PMID 40960515 | DOI 10.1007/s00210-025-04571-4 · Naunyn-Schmiedeberg's archives of pharmacology · 2026 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BCL2 | “Additionally, they significantly elevated B-cell lymphoma 2 (BCL2) and platelet-derived growth factor (PDGF) levels, indicating their potential to mitigate inflammation and promote tissue repair.” | 0.98 | hgnc_dict_v1 |
| phenotype | lymphoma | “Additionally, they significantly elevated B-cell lymphoma 2 (BCL2) and platelet-derived growth factor (PDGF) levels, indicating their potential to mitigate inflammation and promote tissue repair.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TLR4 | “Anti-inflammatory effect of pirfenidone compared to dexamethasone in ulcerative colitis model induced by acetic acid in rats: involvement of miR-146a and TLR4/NF-κB signaling.” | 0.98 | hgnc_dict_v1 |
| phenotype | ulcerative colitis | “Anti-inflammatory effect of pirfenidone compared to dexamethasone in ulcerative colitis model induced by acetic acid in rats: involvement of miR-146a and TLR4/NF-κB signaling.” | 0.98 | phenotype_alias_lexicon_v2 |
Rare aggressive presentation of primary cutaneous diffuse large B-Cell lymphoma, leg type, in the upper arm with concurrent non-small cell lung cancer.
PMID 40449942 | DOI 10.1136/bcr-2024-264401 · BMJ case reports · 2025 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BCL2 | “Histopathological analysis revealed dense dermal lymphoid infiltrate with a non-germinal centre phenotype (CD20+, MUM1+, BCL2+, BCL6+, CD10-).” | 0.98 | hgnc_dict_v1 |
| phenotype | lymphoma | “Rare aggressive presentation of primary cutaneous diffuse large B-Cell lymphoma, leg type, in the upper arm with concurrent non-small cell lung cancer.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | BCL6 | “Histopathological analysis revealed dense dermal lymphoid infiltrate with a non-germinal centre phenotype (CD20+, MUM1+, BCL2+, BCL6+, CD10-).” | 0.98 | hgnc_dict_v1 |
| phenotype | lung cancer | “Rare aggressive presentation of primary cutaneous diffuse large B-Cell lymphoma, leg type, in the upper arm with concurrent non-small cell lung cancer.” | 0.98 | phenotype_alias_lexicon_v2 |
The therapeutic benefits of epigallocatechin gallate in rats with experimentally induced ulcerative colitis are achieved by influencing inflammation and apoptosis.
PMID 40937053 | PMCID PMC12421355 | DOI 10.20524/aog.2025.0985 · Annals of gastroenterology · 2025 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BCL2 | “Colon samples were collected to evaluate gene and protein expression of various factors, including nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), tumor necrosis factor alpha (TNF-α), sphingosine kinase 1 (SphK1), macrophage inflammatory protein 1-alpha (MIP-1α), B-cell lymphoma 2 (BCL2), and BCL2 associated X (BAX), as well as the activities of caspase-3/8/9.” | 0.98 | hgnc_dict_v1 |
| phenotype | lymphoma | “Colon samples were collected to evaluate gene and protein expression of various factors, including nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), tumor necrosis factor alpha (TNF-α), sphingosine kinase 1 (SphK1), macrophage inflammatory protein 1-alpha (MIP-1α), B-cell lymphoma 2 (BCL2), and BCL2 associated X (BAX), as well as the activities of caspase-3/8/9.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | BAX | “Colon samples were collected to evaluate gene and protein expression of various factors, including nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), tumor necrosis factor alpha (TNF-α), sphingosine kinase 1 (SphK1), macrophage inflammatory protein 1-alpha (MIP-1α), B-cell lymphoma 2 (BCL2), and BCL2 associated X (BAX), as well as the activities of caspase-3/8/9.” | 0.98 | hgnc_dict_v1 |
| phenotype | ulcerative colitis | “The therapeutic benefits of epigallocatechin gallate in rats with experimentally induced ulcerative colitis are achieved by influencing inflammation and apoptosis.” | 0.98 | phenotype_alias_lexicon_v2 |
The Potential Protective Effects of EGCG Against Epilepsy-Induced Damage in Rats by Mitigating Oxidative Stress, Inflammation, and Apoptosis.
PMID 41523603 | PMCID PMC12782337 | DOI 10.1155/sci5/8209714 · Scientifica · 2025 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BCL2 | “Furthermore, expressions and concentrations of B-Cell Lymphoma 2 (BCL2), Nuclear Factor Erythroid 2-Related Factor-2 (Nrf2), nuclear factor κB (NFκB), BCL2-associated X (BAX), tumor necrosis factor-α (TNF-α), and Interleukin-1 β (IL-1β) in brain tissues were analyzed.” | 0.98 | hgnc_dict_v1 |
| phenotype | lymphoma | “Furthermore, expressions and concentrations of B-Cell Lymphoma 2 (BCL2), Nuclear Factor Erythroid 2-Related Factor-2 (Nrf2), nuclear factor κB (NFκB), BCL2-associated X (BAX), tumor necrosis factor-α (TNF-α), and Interleukin-1 β (IL-1β) in brain tissues were analyzed.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | epilepsy | “We conducted this study to evaluate the protective effects of Epigallocatechin-3-gallate (EGCG) against epilepsy in rats, with a specific focus on its potential to mitigate oxidative stress, inflammation, and apoptosis.” | 0.98 | phenotype_alias_lexicon_v2 |
Therapeutic effects of genistein in experimentally induced ulcerative colitis in rats via affecting mitochondrial biogenesis.
PMID 37084167 | DOI 10.1007/s11010-023-04746-8 · Molecular and cellular biochemistry · 2024 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BCL2 | “Colon samples were obtained to assess the gene and protein expression of nuclear factor erythroid 2-related factor-2 (Nrf2), heme oxygenase-1 (HO-1), peroxisome proliferator-activated receptor-gamma coactivator (PGC-1), mitochondrial transcription factor A (TFAM), B-cell lymphoma 2 (BCL2), BCL2-associated X (BAX), caspase-3, caspase-8, and caspase-9.” | 0.98 | hgnc_dict_v1 |
| phenotype | lymphoma | “Colon samples were obtained to assess the gene and protein expression of nuclear factor erythroid 2-related factor-2 (Nrf2), heme oxygenase-1 (HO-1), peroxisome proliferator-activated receptor-gamma coactivator (PGC-1), mitochondrial transcription factor A (TFAM), B-cell lymphoma 2 (BCL2), BCL2-associated X (BAX), caspase-3, caspase-8, and caspase-9.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TFAM | “Colon samples were obtained to assess the gene and protein expression of nuclear factor erythroid 2-related factor-2 (Nrf2), heme oxygenase-1 (HO-1), peroxisome proliferator-activated receptor-gamma coactivator (PGC-1), mitochondrial transcription factor A (TFAM), B-cell lymphoma 2 (BCL2), BCL2-associated X (BAX), caspase-3, caspase-8, and caspase-9.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Colon samples were obtained to assess the gene and protein expression of nuclear factor erythroid 2-related factor-2 (Nrf2), heme oxygenase-1 (HO-1), peroxisome proliferator-activated receptor-gamma coactivator (PGC-1), mitochondrial transcription factor A (TFAM), B-cell lymphoma 2 (BCL2), BCL2-associated X (BAX), caspase-3, caspase-8, and caspase-9.” | 0.98 | hgnc_dict_v1 |
Molecular complexity of diffuse large B-cell lymphoma: a molecular perspective and therapeutic implications.
PMID 38001281 | DOI 10.1007/s13353-023-00804-5 · Journal of applied genetics · 2024 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BCL2 | “Genetic investigations, led by high-throughput sequencing, have unveiled recurrent mutations in genes such as MYC, BCL2, and BCL6, casting light on the underlying genetic chaos propelling DLBCL's aggressiveness.” | 0.98 | hgnc_dict_v1 |
| phenotype | lymphoma | “Molecular complexity of diffuse large B-cell lymphoma: a molecular perspective and therapeutic implications.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | MYC | “Genetic investigations, led by high-throughput sequencing, have unveiled recurrent mutations in genes such as MYC, BCL2, and BCL6, casting light on the underlying genetic chaos propelling DLBCL's aggressiveness.” | 0.98 | hgnc_dict_v1 |
| gene | BCL6 | “Genetic investigations, led by high-throughput sequencing, have unveiled recurrent mutations in genes such as MYC, BCL2, and BCL6, casting light on the underlying genetic chaos propelling DLBCL's aggressiveness.” | 0.98 | hgnc_dict_v1 |
Advancing the understanding of venetoclax in t(11;14)-positive multiple myeloma: a comprehensive review of clinical evidence and future prospects.
PMID 38149670 | DOI 10.1080/16078454.2023.2296809 · Hematology (Amsterdam, Netherlands) · 2024 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BCL2 | “Venetoclax is a selective inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (BCL2), as a targeted therapy for multiple myeloma (MM) patients.” | 0.98 | hgnc_dict_v1 |
| phenotype | lymphoma | “Venetoclax is a selective inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (BCL2), as a targeted therapy for multiple myeloma (MM) patients.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | multiple myeloma | “Advancing the understanding of venetoclax in t(11;14)-positive multiple myeloma: a comprehensive review of clinical evidence and future prospects.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | leukemia | “It was initially approved by the United States Food and Drug Administration for the treatment of chronic lymphocytic leukemia in April 2016 and later for acute myeloid leukemia in October 2020.” | 0.98 | phenotype_alias_lexicon_v2 |
Curative effects of crocin in ulcerative colitis via modulating apoptosis and inflammation.
PMID 37030122 | DOI 10.1016/j.intimp.2023.110138 · International immunopharmacology · 2023 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BCL2 | “Moreover, we measured gene and protein expression of B-cell lymphoma 2 (BCL2), BCL2-associated X (BAX), caspase-3/8/9, NF-κB, tumor necrosis factor (TNF)-α and IL-1β/4/6/10.” | 0.98 | hgnc_dict_v1 |
| phenotype | lymphoma | “Moreover, we measured gene and protein expression of B-cell lymphoma 2 (BCL2), BCL2-associated X (BAX), caspase-3/8/9, NF-κB, tumor necrosis factor (TNF)-α and IL-1β/4/6/10.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | BAX | “Moreover, we measured gene and protein expression of B-cell lymphoma 2 (BCL2), BCL2-associated X (BAX), caspase-3/8/9, NF-κB, tumor necrosis factor (TNF)-α and IL-1β/4/6/10.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Moreover, we measured gene and protein expression of B-cell lymphoma 2 (BCL2), BCL2-associated X (BAX), caspase-3/8/9, NF-κB, tumor necrosis factor (TNF)-α and IL-1β/4/6/10.” | 0.98 | hgnc_dict_v1 |
Protective Effect of Vitamin D against Hepatic Molecular Apoptosis Caused by a High-Fat Diet in Rats.
PMID 36661517 | PMCID PMC9857557 | DOI 10.3390/cimb45010031 · Current issues in molecular biology · 2023 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BCL2 | “RNA was extracted from liver tissues and used for the quantitative real-time RT-PCR of different genes: B-cell lymphoma/leukemia-2 (BCL2), BCL-2-associated X protein (Bax), Fas cell surface death receptor (FAS), FAS ligand (FASL), and tumor necrosis factor α (TNF-α).” | 0.98 | hgnc_dict_v1 |
| phenotype | lymphoma | “RNA was extracted from liver tissues and used for the quantitative real-time RT-PCR of different genes: B-cell lymphoma/leukemia-2 (BCL2), BCL-2-associated X protein (Bax), Fas cell surface death receptor (FAS), FAS ligand (FASL), and tumor necrosis factor α (TNF-α).” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | FAS | “RNA was extracted from liver tissues and used for the quantitative real-time RT-PCR of different genes: B-cell lymphoma/leukemia-2 (BCL2), BCL-2-associated X protein (Bax), Fas cell surface death receptor (FAS), FAS ligand (FASL), and tumor necrosis factor α (TNF-α).” | 0.98 | hgnc_dict_v1 |
The therapeutic effects of cycloastragenol in ulcerative colitis by modulating SphK/MIP-1α/miR-143 signalling.
PMID 36029292 | DOI 10.1111/bcpt.13788 · Basic & clinical pharmacology & toxicology · 2022 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BCL2 | “We treated UC rats with 30 mg/kg cycloastragenol and assessed gene and protein expression levels of SphK, MIP-1α, B-cell lymphoma 2 (BCL2), BCL2-associated X (BAX), miR-143, NF-κB, tumour necrosis factor (TNF)-α and active caspase-3.” | 0.98 | hgnc_dict_v1 |
| phenotype | lymphoma | “We treated UC rats with 30 mg/kg cycloastragenol and assessed gene and protein expression levels of SphK, MIP-1α, B-cell lymphoma 2 (BCL2), BCL2-associated X (BAX), miR-143, NF-κB, tumour necrosis factor (TNF)-α and active caspase-3.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | BAX | “We treated UC rats with 30 mg/kg cycloastragenol and assessed gene and protein expression levels of SphK, MIP-1α, B-cell lymphoma 2 (BCL2), BCL2-associated X (BAX), miR-143, NF-κB, tumour necrosis factor (TNF)-α and active caspase-3.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “We treated UC rats with 30 mg/kg cycloastragenol and assessed gene and protein expression levels of SphK, MIP-1α, B-cell lymphoma 2 (BCL2), BCL2-associated X (BAX), miR-143, NF-κB, tumour necrosis factor (TNF)-α and active caspase-3.” | 0.98 | hgnc_dict_v1 |
Immune-antioxidant trait, growth, splenic cytokines expression, apoptosis, and histopathological alterations of Oreochromis niloticus exposed to sub-lethal copper toxicity and fed thyme and/or basil essential oils enriched diets.
PMID 36379445 | DOI 10.1016/j.fsi.2022.11.013 · Fish & shellfish immunology · 2022 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BCL2 | “Furthermore, alteration in the immune-related genes expression (down-regulation of IL-10 and TGF-β and up-regulation of IL-1β, IL-6, IL-8, and TRL-4), hepato-renal dysfunction (elevated ALT, AST, urea, and creatinine), and high levels of serum stress indicators (cortisol and glucose) were markedly evident. sub-lethal Cu toxicity induced significant up-regulation of apoptosis biomarkers involving, nuclear factor-κβ (NF-κβ), Bcl-2 Associated X-protein (BAX), meanwhile, the expression of B-cell lymphoma 2 (BCL2) and Proliferating cell nuclear antigen (PCNA) was remarkably down-regulated.” | 0.98 | hgnc_dict_v1 |
| phenotype | lymphoma | “Furthermore, alteration in the immune-related genes expression (down-regulation of IL-10 and TGF-β and up-regulation of IL-1β, IL-6, IL-8, and TRL-4), hepato-renal dysfunction (elevated ALT, AST, urea, and creatinine), and high levels of serum stress indicators (cortisol and glucose) were markedly evident. sub-lethal Cu toxicity induced significant up-regulation of apoptosis biomarkers involving, nuclear factor-κβ (NF-κβ), Bcl-2 Associated X-protein (BAX), meanwhile, the expression of B-cell lymphoma 2 (BCL2) and Proliferating cell nuclear antigen (PCNA) was remarkably down-regulated.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | BAX | “Furthermore, alteration in the immune-related genes expression (down-regulation of IL-10 and TGF-β and up-regulation of IL-1β, IL-6, IL-8, and TRL-4), hepato-renal dysfunction (elevated ALT, AST, urea, and creatinine), and high levels of serum stress indicators (cortisol and glucose) were markedly evident. sub-lethal Cu toxicity induced significant up-regulation of apoptosis biomarkers involving, nuclear factor-κβ (NF-κβ), Bcl-2 Associated X-protein (BAX), meanwhile, the expression of B-cell lymphoma 2 (BCL2) and Proliferating cell nuclear antigen (PCNA) was remarkably down-regulated.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “Furthermore, alteration in the immune-related genes expression (down-regulation of IL-10 and TGF-β and up-regulation of IL-1β, IL-6, IL-8, and TRL-4), hepato-renal dysfunction (elevated ALT, AST, urea, and creatinine), and high levels of serum stress indicators (cortisol and glucose) were markedly evident. sub-lethal Cu toxicity induced significant up-regulation of apoptosis biomarkers involving, nuclear factor-κβ (NF-κβ), Bcl-2 Associated X-protein (BAX), meanwhile, the expression of B-cell lymphoma 2 (BCL2) and Proliferating cell nuclear antigen (PCNA) was remarkably down-regulated.” | 0.98 | hgnc_dict_v1 |
Association of B-cell lymphoma 2/microRNA-497 gene expression ratio score with metastasis in patients with colorectal cancer: A propensity-matched cohort analysis.
PMID 34994989 | PMCID PMC8841134 | DOI 10.1002/jcla.24227 · Journal of clinical laboratory analysis · 2022 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BCL2 | “Our in silico analysis revealed that miR-497 and its target gene B-cell lymphoma-2 (BCL2) could be related to poor cancer outcomes.” | 0.98 | hgnc_dict_v1 |
| phenotype | lymphoma | “Association of B-cell lymphoma 2/microRNA-497 gene expression ratio score with metastasis in patients with colorectal cancer: A propensity-matched cohort analysis.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | colorectal cancer | “Association of B-cell lymphoma 2/microRNA-497 gene expression ratio score with metastasis in patients with colorectal cancer: A propensity-matched cohort analysis.” | 0.98 | phenotype_alias_lexicon_v2 |
COO and MYC/BCL2 status do not predict outcome among patients with stage I/II DLBCL: a retrospective multicenter study.
PMID 31285189 | PMCID PMC6616265 | DOI 10.1182/bloodadvances.2019000251 · Blood advances · 2019 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BCL2 | “COO and MYC/BCL2 status do not predict outcome among patients with stage I/II DLBCL: a retrospective multicenter study.” | 0.98 | hgnc_dict_v1 |
| phenotype | lymphoma | “In advanced-stage diffuse large B-cell lymphoma (DLBCL), the presence of an activated B-cell phenotype or a non-germinal center (GCB) phenotype, coexpression of MYC and BCL2 by immunohistochemistry, and the cooccurrence of MYC and BCL2 or BCL6 rearrangements are associated with inferior outcomes.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | BCL6 | “In advanced-stage diffuse large B-cell lymphoma (DLBCL), the presence of an activated B-cell phenotype or a non-germinal center (GCB) phenotype, coexpression of MYC and BCL2 by immunohistochemistry, and the cooccurrence of MYC and BCL2 or BCL6 rearrangements are associated with inferior outcomes.” | 0.98 | hgnc_dict_v1 |
Myristica fragrans Kernels Prevent Paracetamol-Induced Hepatotoxicity by Inducing Anti-Apoptotic Genes and Nrf2/HO-1 Pathway.
PMID 30823534 | PMCID PMC6412641 | DOI 10.3390/ijms20040993 · International journal of molecular sciences · 2019 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BCL2 | “APAP intoxication caused a drastic elevation in liver function markers (transaminases, alkaline phosphatase, and total bilirubin), oxidative stress indicators (lipid peroxidation and nitric oxide), inflammatory biomarkers (tumour necrosis factor-α, interleukin-1β, inducible nitric oxide synthase, and nuclear factor ĸB) and the pro-apoptotic BCL2 Associated X (Bax) and caspases-3 genes.” | 0.98 | hgnc_dict_v1 |
| phenotype | lymphoma | “Furthermore, analyses of rat liver tissue revealed that APAP significantly depleted glutathione and inhibited the activities of antioxidant enzymes in addition to downregulating two key anti-apoptotic genes: Cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (c-FLIP) and B-cell lymphoma 2 (Bcl-2).” | 0.98 | phenotype_alias_lexicon_v2 |
Protective Effect of Fragaria ananassa Crude Extract on Cadmium-Induced Lipid Peroxidation, Antioxidant Enzymes Suppression, and Apoptosis in Rat Testes.
PMID 28475120 | PMCID PMC5454870 | DOI 10.3390/ijms18050957 · International journal of molecular sciences · 2017 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BCL2 | “Moreover, gene expression analysis indicated significant upregulation of the pro-apoptotic proteins, bcl-2-associated-X-protein (BAX), and tumor necrosis factor-α (TNFA) in response to cadmium intoxication, while significant downregulation of the anti-apoptotic, B-cell lymphoma 2 (BCL2) gene was detected.” | 0.98 | hgnc_dict_v1 |
| phenotype | lymphoma | “Moreover, gene expression analysis indicated significant upregulation of the pro-apoptotic proteins, bcl-2-associated-X-protein (BAX), and tumor necrosis factor-α (TNFA) in response to cadmium intoxication, while significant downregulation of the anti-apoptotic, B-cell lymphoma 2 (BCL2) gene was detected.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | SOD2 | “Considering cadmium toxicity, the level of the antioxidant enzyme activities including catalase (CAT), superoxide dismutase (SOD2), glutathione peroxidase (GPx1), and glutathione reductase (GR) were markedly decreased.” | 0.98 | hgnc_dict_v1 |
| gene | BAX | “Moreover, gene expression analysis indicated significant upregulation of the pro-apoptotic proteins, bcl-2-associated-X-protein (BAX), and tumor necrosis factor-α (TNFA) in response to cadmium intoxication, while significant downregulation of the anti-apoptotic, B-cell lymphoma 2 (BCL2) gene was detected.” | 0.98 | hgnc_dict_v1 |
IQGAP1 gene silencing induces apoptosis and decreases the invasive capacity of human hepatocellular carcinoma cells.
PMID 27488117 | DOI 10.1007/s13277-016-5283-8 · Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016 · 11 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BCL2 | “We investigated the impact of IQGAP1 silencing on the interactions of IQGAP and RAS with several apoptotic proteins, including caspase-3 (CASP3), BCL2-associated X protein (BAX), and B-cell leukemia/lymphoma 2 (BCL2).” | 0.98 | hgnc_dict_v1 |
| phenotype | lymphoma | “We investigated the impact of IQGAP1 silencing on the interactions of IQGAP and RAS with several apoptotic proteins, including caspase-3 (CASP3), BCL2-associated X protein (BAX), and B-cell leukemia/lymphoma 2 (BCL2).” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | IQGAP1 | “IQGAP1 gene silencing induces apoptosis and decreases the invasive capacity of human hepatocellular carcinoma cells.” | 0.98 | hgnc_dict_v1 |
| gene | IQGAP2 | “IQGAP1 is expressed in all cells, while IQGAP2 and IQGAP3 are mainly expressed in hepatic cells.” | 0.98 | hgnc_dict_v1 |
Multiparameter analysis of homogeneously R-CHOP-treated diffuse large B cell lymphomas identifies CD5 and FOXP1 as relevant prognostic biomarkers: report of the prospective SAKK 38/07 study.
PMID 26071053 | PMCID PMC4472251 | DOI 10.1186/s13045-015-0168-7 · Journal of hematology & oncology · 2015 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BCL2 | “Immunohistochemical (bcl2, bcl6, CD5, CD10, CD20, CD95, CD168, cyclin E, FOXP1, GCET, Ki-67, LMO2, MUM1p, pSTAT3) and in situ hybridization analyses (BCL2 break apart probe, C-MYC break apart probe and C-MYC/IGH double-fusion probe, and Epstein-Barr virus probe) were performed and correlated with the endpoints.” | 0.98 | hgnc_dict_v1 |
| phenotype | lymphoma | “BACKGROUND: The prognostic role of tumor-related parameters in diffuse large B cell lymphoma (DLBCL) is a matter of controversy.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | FOXP1 | “Multiparameter analysis of homogeneously R-CHOP-treated diffuse large B cell lymphomas identifies CD5 and FOXP1 as relevant prognostic biomarkers: report of the prospective SAKK 38/07 study.” | 0.98 | hgnc_dict_v1 |
| gene | LMO2 | “Immunohistochemical (bcl2, bcl6, CD5, CD10, CD20, CD95, CD168, cyclin E, FOXP1, GCET, Ki-67, LMO2, MUM1p, pSTAT3) and in situ hybridization analyses (BCL2 break apart probe, C-MYC break apart probe and C-MYC/IGH double-fusion probe, and Epstein-Barr virus probe) were performed and correlated with the endpoints.” | 0.98 | hgnc_dict_v1 |