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BDNF and Alzheimer disease are reported together in 8 articles.
Gene
BDNF
- HGNC
- HGNC:1033
104articles
104mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
epilepsy 22intellectual disability 13Alzheimer disease 8autism spectrum disorder 8diabetes mellitus 6lymphoma 3multiple sclerosis 3neurodevelopmental disorder 2
Reported variants (articles · ClinVar status)
Phenotype
Alzheimer disease
455articles
455mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
8 records shown · first 60Adenosine A₂A receptor as a dual-acting molecular switch: Glial morphological changes and neurovascular tissue remodeling in neuroinflammation and neurodegeneration.
PMID 41690071 | DOI 10.1016/j.tice.2026.103389 · Tissue & cell · 2026 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BDNF | “Acute or transient (short-term) A₂AR activation, on the other hand, increases the production of anti-inflammatory cytokines like IL-10 and enhances neurotrophic support through BDNF.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Neuroinflammation appears in a variety of neurological disorders, including multiple sclerosis (MS), Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | multiple sclerosis | “Neuroinflammation appears in a variety of neurological disorders, including multiple sclerosis (MS), Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | amyotrophic lateral sclerosis | “Neuroinflammation appears in a variety of neurological disorders, including multiple sclerosis (MS), Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis.” | 0.98 | phenotype_alias_lexicon_v2 |
Beyond categorical boundaries: Common molecular and cellular pathways in autism spectrum disorder and schizophrenia.
PMID 42276200 | DOI 10.1016/j.pnpbp.2026.111774 · Progress in neuro-psychopharmacology & biological psychiatry · 2026 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BDNF | “These include dysregulation of the dopaminergic, serotonergic, glutamatergic, GABAergic, and acetylcholinergic systems; changes in BDNF signaling; histamine dysregulation; microglial activation; neuroinflammation; complement-mediated synapse elimination; gut-brain axis signaling; and endocannabinoid system dysfunction.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “It is important to note that the aforementioned biological mechanisms are present in several CNS disorders, such as major depressive disorder, Alzheimer's disease, and multiple sclerosis.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | autism spectrum disorder | “Beyond categorical boundaries: Common molecular and cellular pathways in autism spectrum disorder and schizophrenia.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | neurodevelopmental disorder | “Historically, ASD and schizophrenia have been classified as two distinct disorders, one being a neurodevelopmental disorder and the other a psychotic disorder.” | 0.98 | phenotype_alias_lexicon_v2 |
Taurine and Neuroprotection: A Potential Shield Against Methylglyoxal-Induced Toxicity in SH-SY5Y Cells.
PMID 40586270 | DOI 10.1002/jbt.70343 · Journal of biochemical and molecular toxicology · 2025 · 13 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BDNF | “The results showed that when SH-SY5Y cells are exposed to MG (2400 μM) + taurine (1.5 mg/mL), genes SHH, BMP2, ERBB2, NEUROG2, BDNF, POU3F3, PARD3, PAX3, NR2E3, NRP2, CXCL1, and EGF had a significant increase (p < 0.005).” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Methylglyoxal (MG) is thought to have harmful effects on Alzheimer's disease (AD).” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | SHH | “The results showed that when SH-SY5Y cells are exposed to MG (2400 μM) + taurine (1.5 mg/mL), genes SHH, BMP2, ERBB2, NEUROG2, BDNF, POU3F3, PARD3, PAX3, NR2E3, NRP2, CXCL1, and EGF had a significant increase (p < 0.005).” | 0.98 | hgnc_dict_v1 |
| gene | BMP2 | “The results showed that when SH-SY5Y cells are exposed to MG (2400 μM) + taurine (1.5 mg/mL), genes SHH, BMP2, ERBB2, NEUROG2, BDNF, POU3F3, PARD3, PAX3, NR2E3, NRP2, CXCL1, and EGF had a significant increase (p < 0.005).” | 0.98 | hgnc_dict_v1 |
Role of ketogenic diet in neurodegenerative diseases focusing on Alzheimer diseases: The guardian angle.
PMID 38360180 | DOI 10.1016/j.arr.2024.102233 · Ageing research reviews · 2024 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BDNF | “In conclusion, KD improves cognitive function and attenuates the progression of AD neuropathology by reducing oxidative stress, mitochondrial dysfunction, and enhancing neuronal autophagy and brain BDNF.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Alzheimer disease (AD) is the first common neurodegenerative disease in the world characterized by memory and cognitive impairment.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | epilepsy | “KD is primarily used to treat refractory epilepsy.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | intellectual disability | “Alzheimer disease (AD) is the first common neurodegenerative disease in the world characterized by memory and cognitive impairment.” | 0.93 | phenotype_alias_lexicon_v2 |
Exercise modulates APOE expression in brain cortex of female APOE3 and APOE4 targeted replacement mice.
PMID 36434832 | PMCID PMC9839612 | DOI 10.1016/j.npep.2022.102307 · Neuropeptides · 2023 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BDNF | “Several studies indicate that APOE4 modulates critical factors for neuronal function, including brain-derived neurotrophic factor (BDNF) and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α).” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Apolipoprotein E (ApoE) is the main cholesterol carrier of the brain and the ε4 gene variant (APOE4) is the most prevalent genetic risk factor for Alzheimer's disease (AD), increasing risk up to 15-fold.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | APOE | “Exercise modulates APOE expression in brain cortex of female APOE3 and APOE4 targeted replacement mice.” | 0.98 | hgnc_dict_v1 |
Memory Impairment, Pro-Inflammatory Host Response and Brain Histopathologic Severity in Rats Infected with K. pneumoniae or P. aeruginosa Meningitis.
PMID 36015052 | PMCID PMC9416464 | DOI 10.3390/pathogens11080933 · Pathogens (Basel, Switzerland) · 2022 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BDNF | “Cerebrospinal fluid (CSF) culture, relative brain weights, complete blood analysis, biochemical markers, levels of cytokine, chemokine and brain-derived neurotrophic factor (BDNF), neurotransmitter acetylcholine esterase (AChE) activity, and the brain histopathology of the infected rats in comparison to those in the control group were assessed.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “This model may be utilized for further investigation to ascertain the molecular and biological association between bacterial meningitis and the development of the pathophysiological hallmarks underlying Alzheimer's disease in preclinical and clinical setups.” | 0.93 | phenotype_alias_lexicon_v2 |
Association between the Val66Met polymorphism (rs6265/G196A) of the BDNF gene and cognitive performance with SSRI use in Arab Alzheimer's disease patients.
PMID 35002376 | PMCID PMC8720700 | DOI 10.1016/j.jsps.2021.10.007 · Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2021 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BDNF | “Association between the Val66Met polymorphism (rs6265/G196A) of the BDNF gene and cognitive performance with SSRI use in Arab Alzheimer's disease patients.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Association between the Val66Met polymorphism (rs6265/G196A) of the BDNF gene and cognitive performance with SSRI use in Arab Alzheimer's disease patients.” | 0.93 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Healthy young, middle ages (25-59 years old) and elderly (more than 60 years old) participants (140) as well as 40 AD patients of whom are both of Saudi Arabian origin were recruited.” | 0.95 | saudi_context_rules_v1 |
| variant | rs6265 | “Association between the Val66Met polymorphism (rs6265/G196A) of the BDNF gene and cognitive performance with SSRI use in Arab Alzheimer's disease patients.” | 0.90 | hgvs_regex_v1 |
Neurotrophic Treatment Initiated During Early Postnatal Development Prevents the Alzheimer-Like Behavior and Synaptic Dysfunction.
PMID 34057082 | PMCID PMC8385525 | DOI 10.3233/JAD-201599 · Journal of Alzheimer's disease : JAD · 2021 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BDNF | “RESULTS: P021 treatment during early development prevented cognitive impairment and increased expressions of pCREB and BDNF that activated downstream various signaling cascades such as PLC/PKC, MEK/ERK and PI3K/Akt, and ameliorated synaptic protein deficit in 4-month-old 3xTg-AD mice.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by impairments in synaptic plasticity and cognitive performance.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CNTF | “METHODS: In the present study, we investigated the effect of treatment during early development with a ciliary neurotrophic factor (CNTF) derived peptidergic compound, P021 (Ac-DGGLAG-NH2) on cognitive function and synaptic plasticity in 3xTg-AD transgenic mouse model of AD.” | 0.98 | hgnc_dict_v1 |
| phenotype | intellectual disability | “RESULTS: P021 treatment during early development prevented cognitive impairment and increased expressions of pCREB and BDNF that activated downstream various signaling cascades such as PLC/PKC, MEK/ERK and PI3K/Akt, and ameliorated synaptic protein deficit in 4-month-old 3xTg-AD mice.” | 0.93 | phenotype_alias_lexicon_v2 |