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BDNF and multiple sclerosis are reported together in 3 articles.
Gene
BDNF
- HGNC
- HGNC:1033
104articles
104mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
epilepsy 22intellectual disability 13Alzheimer disease 8autism spectrum disorder 8diabetes mellitus 6lymphoma 3multiple sclerosis 3neurodevelopmental disorder 2
Reported variants (articles · ClinVar status)
Phenotype
Multiple sclerosis
236articles
236mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Adenosine A₂A receptor as a dual-acting molecular switch: Glial morphological changes and neurovascular tissue remodeling in neuroinflammation and neurodegeneration.
PMID 41690071 | DOI 10.1016/j.tice.2026.103389 · Tissue & cell · 2026 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BDNF | “Acute or transient (short-term) A₂AR activation, on the other hand, increases the production of anti-inflammatory cytokines like IL-10 and enhances neurotrophic support through BDNF.” | 0.98 | hgnc_dict_v1 |
| phenotype | multiple sclerosis | “Neuroinflammation appears in a variety of neurological disorders, including multiple sclerosis (MS), Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | amyotrophic lateral sclerosis | “Neuroinflammation appears in a variety of neurological disorders, including multiple sclerosis (MS), Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | Alzheimer disease | “Neuroinflammation appears in a variety of neurological disorders, including multiple sclerosis (MS), Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis.” | 0.93 | phenotype_alias_lexicon_v2 |
Beyond categorical boundaries: Common molecular and cellular pathways in autism spectrum disorder and schizophrenia.
PMID 42276200 | DOI 10.1016/j.pnpbp.2026.111774 · Progress in neuro-psychopharmacology & biological psychiatry · 2026 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BDNF | “These include dysregulation of the dopaminergic, serotonergic, glutamatergic, GABAergic, and acetylcholinergic systems; changes in BDNF signaling; histamine dysregulation; microglial activation; neuroinflammation; complement-mediated synapse elimination; gut-brain axis signaling; and endocannabinoid system dysfunction.” | 0.98 | hgnc_dict_v1 |
| phenotype | multiple sclerosis | “It is important to note that the aforementioned biological mechanisms are present in several CNS disorders, such as major depressive disorder, Alzheimer's disease, and multiple sclerosis.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | autism spectrum disorder | “Beyond categorical boundaries: Common molecular and cellular pathways in autism spectrum disorder and schizophrenia.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | neurodevelopmental disorder | “Historically, ASD and schizophrenia have been classified as two distinct disorders, one being a neurodevelopmental disorder and the other a psychotic disorder.” | 0.98 | phenotype_alias_lexicon_v2 |
The janus face of astrocytes in multiple sclerosis: Balancing protection and pathology.
PMID 40288545 | DOI 10.1016/j.brainresbull.2025.111356 · Brain research bulletin · 2025 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BDNF | “Conversely, they also support repair through neurotrophic factor release (e.g., BDNF, CNTF) and remyelination.” | 0.98 | hgnc_dict_v1 |
| phenotype | multiple sclerosis | “The janus face of astrocytes in multiple sclerosis: Balancing protection and pathology.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CNTF | “Conversely, they also support repair through neurotrophic factor release (e.g., BDNF, CNTF) and remyelination.” | 0.98 | hgnc_dict_v1 |