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BRCA1 and leukemia are reported together in 3 articles.
Gene
BRCA1
- HGNC
- HGNC:1100
132articles
132mentions
5variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 92ovarian cancer 26prostate cancer 9colorectal cancer 5diabetes mellitus 3gastric cancer 3leukemia 3lung cancer 3
Reported variants (articles · ClinVar status)
Phenotype
Leukemia
652articles
652mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Gene Expression Analysis of Pediatric Acute Myeloid Leukemia Identified a Hyperactive ASXL1/BAP1 Axis Linked with Poor Prognosis and over Expressed Epigenetic Modifiers.
PMID 33764257 | DOI 10.1080/08880018.2021.1901808 · Pediatric hematology and oncology · 2021 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BRCA1 | “Our data showed that high ASXL1 mRNA is interrelated with increased BRCA1 associated protein-1 (BAP1) and its target gene E2F Transcription Factor 1 (E2F1) expression.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “Gene Expression Analysis of Pediatric Acute Myeloid Leukemia Identified a Hyperactive ASXL1/BAP1 Axis Linked with Poor Prognosis and over Expressed Epigenetic Modifiers.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | ASXL1 | “Gene Expression Analysis of Pediatric Acute Myeloid Leukemia Identified a Hyperactive ASXL1/BAP1 Axis Linked with Poor Prognosis and over Expressed Epigenetic Modifiers.” | 0.98 | hgnc_dict_v1 |
| gene | BAP1 | “Gene Expression Analysis of Pediatric Acute Myeloid Leukemia Identified a Hyperactive ASXL1/BAP1 Axis Linked with Poor Prognosis and over Expressed Epigenetic Modifiers.” | 0.98 | hgnc_dict_v1 |
Frequency of pathogenic/likely pathogenic germline variants in cancer-related genes among children with acute leukemia in Saudi Arabia.
PMID 32359129 | DOI 10.1002/pbc.28340 · Pediatric blood & cancer · 2020 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BRCA1 | “Three patients with B-ALL had heterozygous pathogenic mutations in TP53, BRCA1, and BRCA2; one patient with B-ALL had homozygous pathogenic mutation in PMS2; and one patient with T-ALL had LP homozygous mutation in AK2 that was associated with reticular dysgenesis.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “Frequency of pathogenic/likely pathogenic germline variants in cancer-related genes among children with acute leukemia in Saudi Arabia.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TP53 | “Three patients with B-ALL had heterozygous pathogenic mutations in TP53, BRCA1, and BRCA2; one patient with B-ALL had homozygous pathogenic mutation in PMS2; and one patient with T-ALL had LP homozygous mutation in AK2 that was associated with reticular dysgenesis.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA2 | “Three patients with B-ALL had heterozygous pathogenic mutations in TP53, BRCA1, and BRCA2; one patient with B-ALL had homozygous pathogenic mutation in PMS2; and one patient with T-ALL had LP homozygous mutation in AK2 that was associated with reticular dysgenesis.” | 0.98 | hgnc_dict_v1 |
Gene expression analysis approach to establish possible links between Parkinson's disease, cancer and cardiovascular diseases.
PMID 25345512 | DOI 10.2174/1871527313666141023122803 · CNS & neurological disorders drug targets · 2014 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BRCA1 | “We integrated these data with known pathways using Ingenuity Pathway Analysis tool and found following common pathways associated with all three diseases to be most affected; epithelial adherens junction signaling, remodelling of epithelial adherens junctions, role of BRCA1 in DNA damage response, sphingomyelin metabolism, 3- phosphoinositide biosynthesis, acute myeloid leukemia signaling, type I diabetes mellitus signaling, agrin interactions at neuromuscular junction, role of IL-17A in arthritis, and antigen presentation pathways.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “We integrated these data with known pathways using Ingenuity Pathway Analysis tool and found following common pathways associated with all three diseases to be most affected; epithelial adherens junction signaling, remodelling of epithelial adherens junctions, role of BRCA1 in DNA damage response, sphingomyelin metabolism, 3- phosphoinositide biosynthesis, acute myeloid leukemia signaling, type I diabetes mellitus signaling, agrin interactions at neuromuscular junction, role of IL-17A in arthritis, and antigen presentation pathways.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | Parkinson disease | “Gene expression analysis approach to establish possible links between Parkinson's disease, cancer and cardiovascular diseases.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | diabetes mellitus | “Cardiovascular diseases (CVD), cancer, diabetes and neurodegenerative diseases are collectively amounting to more than 60% of non-communicable disease burden across world.” | 0.93 | phenotype_alias_lexicon_v2 |