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BRCA1 and obesity are reported together in 2 articles.
Gene
BRCA1
- HGNC
- HGNC:1100
132articles
132mentions
5variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 92ovarian cancer 26prostate cancer 9colorectal cancer 5diabetes mellitus 3gastric cancer 3leukemia 3lung cancer 3
Reported variants (articles · ClinVar status)
Phenotype
Obesity
- HPO
- HP:0001513
856articles
856mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Male Breast Cancer: Epidemiology, Diagnosis, Molecular Mechanisms, Therapeutics, and Future Prospective.
PMID 41502531 | PMCID PMC12774558 | DOI 10.32604/or.2025.068238 · Oncology research · 2025 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BRCA1 | “Major risk factors include hormonal imbalance, radiation exposure, obesity, alcohol use, and Breast Cancer Gene 1 and 2 (BRCA1/2) mutations.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “Major risk factors include hormonal imbalance, radiation exposure, obesity, alcohol use, and Breast Cancer Gene 1 and 2 (BRCA1/2) mutations.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | EGFR | “Molecular mechanisms involve hormonal signaling, HER2/epidermal growth factor receptor (EGFR) pathways, tumor suppressor gene alterations, and epigenetic changes.” | 0.98 | hgnc_dict_v1 |
| gene | CDK4 | “While standard treatments mirror those for female breast cancer, emerging options such as cyclin-dependent kinase 4 and 6 (CDK4/6), and poly(ADP-ribose) polymerase (PARP) inhibitors, immunotherapy, and precision medicine are reshaping management.” | 0.98 | hgnc_dict_v1 |
Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2.
PMID 36812344 | PMCID PMC10557057 | DOI 10.1126/scitranslmed.ade1857 · Science translational medicine · 2023 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BRCA1 | “Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | BRCA2 | “Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Obesity, defined as a body mass index (BMI) ≥ 30, is an established risk factor for breast cancer among women in the general population after menopause.” | 0.98 | phenotype_alias_lexicon_v2 |