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BRCA2 and leukemia are reported together in 3 articles.
Gene
BRCA2
- HGNC
- HGNC:1101
95articles
95mentions
6variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 57ovarian cancer 18prostate cancer 10colorectal cancer 6thyroid cancer 4gastric cancer 3leukemia 3diabetes mellitus 1
Reported variants (articles · ClinVar status)
Phenotype
Leukemia
652articles
652mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Omics and artificial intelligence integration for stratifying blast crisis CML using COSMIC signatures and pan-cancer precision drug repurposing.
PMID 41355924 | PMCID PMC12678951 | DOI 10.5306/wjco.v16.i11.111983 · World journal of clinical oncology · 2025 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BRCA2 | “ML identified three BC-CML clusters: (1) Cluster 1 [breast cancer susceptibility gene 2 (BRCA2), TP53]; (2) Cluster 2 [isocitrate dehydrogenase (IDH) 1/2, ten-eleven translocation 2]; and (3) Cluster 3 [Janus kinase (JAK) 2, colony-stimulating factor 3 receptor], with distinct COSMIC signatures.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “BACKGROUND: Although chronic-phase chronic myeloid leukemia (CP-CML) is treatable and nearly curable in about 50% of patients, accelerated-phase chronic myeloid leukemia (AP-CML) shows concerning drug resistance, while blast crisis chronic myeloid leukemia (BC-CML) is highly lethal.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TP53 | “ML identified three BC-CML clusters: (1) Cluster 1 [breast cancer susceptibility gene 2 (BRCA2), TP53]; (2) Cluster 2 [isocitrate dehydrogenase (IDH) 1/2, ten-eleven translocation 2]; and (3) Cluster 3 [Janus kinase (JAK) 2, colony-stimulating factor 3 receptor], with distinct COSMIC signatures.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “ML identified three BC-CML clusters: (1) Cluster 1 [breast cancer susceptibility gene 2 (BRCA2), TP53]; (2) Cluster 2 [isocitrate dehydrogenase (IDH) 1/2, ten-eleven translocation 2]; and (3) Cluster 3 [Janus kinase (JAK) 2, colony-stimulating factor 3 receptor], with distinct COSMIC signatures.” | 0.98 | phenotype_alias_lexicon_v2 |
Frequency of pathogenic/likely pathogenic germline variants in cancer-related genes among children with acute leukemia in Saudi Arabia.
PMID 32359129 | DOI 10.1002/pbc.28340 · Pediatric blood & cancer · 2020 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BRCA2 | “Three patients with B-ALL had heterozygous pathogenic mutations in TP53, BRCA1, and BRCA2; one patient with B-ALL had homozygous pathogenic mutation in PMS2; and one patient with T-ALL had LP homozygous mutation in AK2 that was associated with reticular dysgenesis.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “Frequency of pathogenic/likely pathogenic germline variants in cancer-related genes among children with acute leukemia in Saudi Arabia.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TP53 | “Three patients with B-ALL had heterozygous pathogenic mutations in TP53, BRCA1, and BRCA2; one patient with B-ALL had homozygous pathogenic mutation in PMS2; and one patient with T-ALL had LP homozygous mutation in AK2 that was associated with reticular dysgenesis.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Three patients with B-ALL had heterozygous pathogenic mutations in TP53, BRCA1, and BRCA2; one patient with B-ALL had homozygous pathogenic mutation in PMS2; and one patient with T-ALL had LP homozygous mutation in AK2 that was associated with reticular dysgenesis.” | 0.98 | hgnc_dict_v1 |
Clinical characteristics and genetic subtypes of Fanconi anemia in Saudi patients.
PMID 26968956 | DOI 10.1016/j.cancergen.2016.02.003 · Cancer genetics · 2016 · 12 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BRCA2 | “Three patients presented with early onset of cancer, two had BRCA2 mutation c.7007G > A (p.Arg2336His) and one had a novel c.3425del (p.Leu1142Tyrfs*21) PALB2 mutation.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “One individual with SAA and acute myeloid leukemia had c.637_643del (p.Tyr213Lysfs*6) FANCG mutation.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | BRIP1 | “Four patients with severe aplastic anemia (SAA) had c.2392C > T (p.Arg798*) BRIP1/FANCJ mutation.” | 0.98 | hgnc_dict_v1 |
| gene | FANCC | “Another child with SAA had novel c.1475T > C (p.Leu492Pro) FANCC mutation.” | 0.98 | hgnc_dict_v1 |