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CCL2 and metabolic syndrome are reported together in 2 articles.
Gene
CCL2
- HGNC
- HGNC:10618
35articles
35mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
diabetes mellitus 4lung cancer 3COVID-19 2metabolic syndrome 2MERS 1amyotrophic lateral sclerosis 1hepatitis C 1obesity 1
Reported variants (articles · ClinVar status)
Phenotype
Metabolic syndrome
141articles
141mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Modulation of Pulmonary Toxicity in Metabolic Syndrome Due to Variations in Iron Oxide Nanoparticle-Biocorona Composition.
PMID 35745361 | PMCID PMC9230893 | DOI 10.3390/nano12122022 · Nanomaterials (Basel, Switzerland) · 2022 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CCL2 | “Macrophages exposed to Fe3O4 NPs with a MetS-BC for 1 h or 24 h at a concentration of 25 μg/mL demonstrated enhanced gene expression of inflammatory markers: CCL2, IL-6, and TNF-α compared to Fe3O4 NPs with a healthy BC.” | 0.98 | hgnc_dict_v1 |
| phenotype | metabolic syndrome | “Modulation of Pulmonary Toxicity in Metabolic Syndrome Due to Variations in Iron Oxide Nanoparticle-Biocorona Composition.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | STAT3 | “Western blot analysis revealed activation of STAT3, NF-κB, and ERK pathways due to the MetS-BC.” | 0.98 | hgnc_dict_v1 |
Comparison of silver nanoparticle-induced inflammatory responses between healthy and metabolic syndrome mouse models.
PMID 32281499 | PMCID PMC7493428 | DOI 10.1080/15287394.2020.1748779 · Journal of toxicology and environmental health. Part A · 2020 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CCL2 | “Mice were injected with 2 mg/kg AgNPs, and organs assessed for inflammatory gene expression (TNF-α, CXCL1, CXCL2, CCL2, TGF-β, HO-1, IL-4, IL-13), and Ag content.” | 0.98 | hgnc_dict_v1 |
| phenotype | metabolic syndrome | “Comparison of silver nanoparticle-induced inflammatory responses between healthy and metabolic syndrome mouse models.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CXCL1 | “Mice were injected with 2 mg/kg AgNPs, and organs assessed for inflammatory gene expression (TNF-α, CXCL1, CXCL2, CCL2, TGF-β, HO-1, IL-4, IL-13), and Ag content.” | 0.98 | hgnc_dict_v1 |
| gene | CXCL2 | “Mice were injected with 2 mg/kg AgNPs, and organs assessed for inflammatory gene expression (TNF-α, CXCL1, CXCL2, CCL2, TGF-β, HO-1, IL-4, IL-13), and Ag content.” | 0.98 | hgnc_dict_v1 |