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CCND1 and leukemia are reported together in 3 articles.
Gene
CCND1
- HGNC
- HGNC:1582
39articles
39mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
colorectal cancer 9breast cancer 8leukemia 3prostate cancer 2Parkinson disease 1diabetes mellitus 1hepatitis B 1hepatocellular carcinoma 1
Reported variants (articles · ClinVar status)
Phenotype
Leukemia
652articles
652mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Differential Expression and Target Gene Analysis of PBMC-Derived microRNAs as Prognostic Biomarkers in Acute Lymphoblastic Leukemia.
PMID 42123456 | PMCID PMC13163416 | DOI 10.3390/ijms27093868 · International journal of molecular sciences · 2026 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CCND1 | “Validated targets concentrated on key leukemia-related genes like PTEN, BCL2L11, CDKN1A, CCND1, RB1, E2F1, and TGFBR2.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “Differential Expression and Target Gene Analysis of PBMC-Derived microRNAs as Prognostic Biomarkers in Acute Lymphoblastic Leukemia.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | PTEN | “Validated targets concentrated on key leukemia-related genes like PTEN, BCL2L11, CDKN1A, CCND1, RB1, E2F1, and TGFBR2.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2L11 | “Validated targets concentrated on key leukemia-related genes like PTEN, BCL2L11, CDKN1A, CCND1, RB1, E2F1, and TGFBR2.” | 0.98 | hgnc_dict_v1 |
Coexistence of chronic myeloid leukemia and diffuse large B-cell lymphoma with antecedent chronic lymphocytic leukemia: a case report and review of the literature.
PMID 29524963 | PMCID PMC5845776 | DOI 10.1186/s13256-018-1612-4 · Journal of medical case reports · 2018 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CCND1 | “Purine analog therapy and the presence of trisomy 12, and CCND1 gene rearrangement have been linked to increased risk of Richter's transformation.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “Coexistence of chronic myeloid leukemia and diffuse large B-cell lymphoma with antecedent chronic lymphocytic leukemia: a case report and review of the literature.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | lymphoma | “Coexistence of chronic myeloid leukemia and diffuse large B-cell lymphoma with antecedent chronic lymphocytic leukemia: a case report and review of the literature.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | hypertension | “CASE PRESENTATION: A 60-year-old Saudi man known to have diabetes, hypertension, and chronic active hepatitis B was diagnosed as having Rai stage II chronic lymphocytic leukemia, with trisomy 12 and rearrangement of the CCND1 gene in December 2012.” | 0.98 | phenotype_alias_lexicon_v2 |
Prediction of deleterious single nucleotide polymorphisms and their effect on the sequence and structure of the human CCND1 gene.
PMID 31435243 | PMCID PMC6695066 | DOI 10.1016/j.jtumed.2016.07.009 · Journal of Taibah University Medical Sciences · 2017 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CCND1 | “Prediction of deleterious single nucleotide polymorphisms and their effect on the sequence and structure of the human CCND1 gene.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “This, in turn, may lead to the development of acute myeloid leukaemia (AML).” | 0.93 | phenotype_alias_lexicon_v2 |
| variant | c.648C>G | “CONCLUSION: Based on this study, we propose that the SNP with SNP ID rs112525097 (NM_053056.2:c.648C>G) might cause aberrations in CCND1, which might lead to a change in the function of the G1/S-specific cyclin protein.” | 0.95 | hgvs_regex_v1 |
| variant | rs112525097 | “CONCLUSION: Based on this study, we propose that the SNP with SNP ID rs112525097 (NM_053056.2:c.648C>G) might cause aberrations in CCND1, which might lead to a change in the function of the G1/S-specific cyclin protein.” | 0.90 | hgvs_regex_v1 |