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CCR5 and HIV infection are reported together in 3 articles.
Gene
CCR5
- HGNC
- HGNC:1606
25articles
25mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
autism spectrum disorder 4HIV infection 3diabetes mellitus 3neurodevelopmental disorder 3obesity 2asthma 1coronary artery disease 1infertility 1
Reported variants (articles · ClinVar status)
Phenotype
HIV infection
146articles
146mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Unlocking the role of transcription activator-like effector nuclease (TALENs) and zinc finger nuclease (ZFN) in the treatment of HIV.
PMID 41003754 | DOI 10.1007/s11033-025-10993-3 · Molecular biology reports · 2025 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CCR5 | “These include the entrance receptors CCR5 and CXCR4, as well as the proviral integration protein LEDGF/p75.” | 0.98 | hgnc_dict_v1 |
| phenotype | HIV infection | “Unlocking the role of transcription activator-like effector nuclease (TALENs) and zinc finger nuclease (ZFN) in the treatment of HIV.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CXCR4 | “These include the entrance receptors CCR5 and CXCR4, as well as the proviral integration protein LEDGF/p75.” | 0.98 | hgnc_dict_v1 |
Treatment strategies for HIV infection with emphasis on role of CRISPR/Cas9 gene: Success so far and road ahead.
PMID 35940236 | DOI 10.1016/j.ejphar.2022.175173 · European journal of pharmacology · 2022 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CCR5 | “The potential benefits of specific epigenetic modification in the c-c chemokine receptor 5 gene (CCR5) via various delivery methods are also highlighted.” | 0.98 | hgnc_dict_v1 |
| phenotype | HIV infection | “Treatment strategies for HIV infection with emphasis on role of CRISPR/Cas9 gene: Success so far and road ahead.” | 0.98 | phenotype_alias_lexicon_v2 |
The prevalence of CCR5-Δ32 mutation in a cohort of Saudi stem cell donors.
PMID 28731615 | DOI 10.1111/tan.13100 · HLA · 2017 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CCR5 | “CCR5 is a chemokine receptor that was found to be used by HIV as a co-receptor for entering target cells.” | 0.98 | hgnc_dict_v1 |
| phenotype | HIV infection | “CCR5 is a chemokine receptor that was found to be used by HIV as a co-receptor for entering target cells.” | 0.93 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “The prevalence of CCR5-Δ32 mutation in a cohort of Saudi stem cell donors. We found 38 heterozygous for CCR5-Δ32 and one homozygous CCR5 mutation (Δ32/Δ32) out of the 3025 tested individuals. We conclude that the protective CCR5-Δ32 allele appears to be rarely present in Saudi Arabia.” | 0.95 | saudi_context_rules_v1 |