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CCR5 and diabetes mellitus are reported together in 3 articles.
Gene
CCR5
- HGNC
- HGNC:1606
25articles
25mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
autism spectrum disorder 4HIV infection 3diabetes mellitus 3neurodevelopmental disorder 3obesity 2asthma 1coronary artery disease 1infertility 1
Reported variants (articles · ClinVar status)
Phenotype
Diabetes mellitus
2,156articles
2,156mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Dysregulated Vitamin D, CYP2R1, TCF7L2, and CCR5 Δ32 Gene Variations are Associated with Coronary Artery Disease.
PMID 39600283 | DOI 10.24976/Discov.Med.202436190.210 · Discovery medicine · 2024 · 10 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CCR5 | “Dysregulated Vitamin D, CYP2R1, TCF7L2, and CCR5 Δ32 Gene Variations are Associated with Coronary Artery Disease.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “BACKGROUND: Insufficient vitamin D (vit D) levels are associated with various chronic conditions such as cancers, autoimmune diseases, diabetes, and cardiovascular diseases, notably coronary artery disease (CAD).” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CYP2R1 | “Dysregulated Vitamin D, CYP2R1, TCF7L2, and CCR5 Δ32 Gene Variations are Associated with Coronary Artery Disease.” | 0.98 | hgnc_dict_v1 |
| gene | TCF7L2 | “Dysregulated Vitamin D, CYP2R1, TCF7L2, and CCR5 Δ32 Gene Variations are Associated with Coronary Artery Disease.” | 0.98 | hgnc_dict_v1 |
Meta-analysis of diabetic nephropathy associated genetic variants in inflammation and angiogenesis involved in different biochemical pathways.
PMID 25280384 | PMCID PMC4411872 | DOI 10.1186/s12881-014-0103-8 · BMC medical genetics · 2014 · 11 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CCR5 | “These included genetic variants within or near VEGFA, CCR5, CCL2, IL-1, MMP9, EPO, IL-8, ADIPOQ and IL-10. rs1800871 (T) genetic variant in IL-10 showed protective effect for DN.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “BACKGROUND: Diabetes mellitus is the most common chronic endocrine disorder, affecting an estimated population of 382 million people worldwide.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | VEGFA | “These included genetic variants within or near VEGFA, CCR5, CCL2, IL-1, MMP9, EPO, IL-8, ADIPOQ and IL-10. rs1800871 (T) genetic variant in IL-10 showed protective effect for DN.” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “These included genetic variants within or near VEGFA, CCR5, CCL2, IL-1, MMP9, EPO, IL-8, ADIPOQ and IL-10. rs1800871 (T) genetic variant in IL-10 showed protective effect for DN.” | 0.98 | hgnc_dict_v1 |
Chemokine expression is upregulated in chondrocytes in diabetic fracture healing.
PMID 23262028 | PMCID PMC3767396 | DOI 10.1016/j.bone.2012.12.006 · Bone · 2013 · 12 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CCR5 | “Diabetes significantly upregulated mRNA levels of several chemokines in vivo including CCL4, CCL8, CCL6, CCL11, CCL20, CCL24, CXCL2, CXCL5 and chemokine receptors CCR5 and CXCR4.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “We investigated the impact of diabetes on chemokine expression in normal and diabetic fracture healing.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CCL4 | “CCL4 were examined in fracture calluses by immunohistochemistry and the role of TNF in diabetes-enhanced expression was investigated by treatment of animals with the TNF-specific inhibitor, pegsunercept.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “CCL4 were examined in fracture calluses by immunohistochemistry and the role of TNF in diabetes-enhanced expression was investigated by treatment of animals with the TNF-specific inhibitor, pegsunercept.” | 0.98 | hgnc_dict_v1 |