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CCR5 and obesity are reported together in 2 articles.
Gene
CCR5
- HGNC
- HGNC:1606
25articles
25mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
autism spectrum disorder 4HIV infection 3diabetes mellitus 3neurodevelopmental disorder 3obesity 2asthma 1coronary artery disease 1infertility 1
Reported variants (articles · ClinVar status)
Phenotype
Obesity
- HPO
- HP:0001513
856articles
856mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Dysregulated Vitamin D, CYP2R1, TCF7L2, and CCR5 Δ32 Gene Variations are Associated with Coronary Artery Disease.
PMID 39600283 | DOI 10.24976/Discov.Med.202436190.210 · Discovery medicine · 2024 · 10 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CCR5 | “Dysregulated Vitamin D, CYP2R1, TCF7L2, and CCR5 Δ32 Gene Variations are Associated with Coronary Artery Disease.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “Additionally, the transcription factor 7-like 2 (TCF7L2), part of the Wnt signaling pathway, regulates glucose homeostasis and the development of tissues, brain, liver and muscles and has been linked to obesity, insulin insensitivity, and elevated blood sugar levels.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CYP2R1 | “Dysregulated Vitamin D, CYP2R1, TCF7L2, and CCR5 Δ32 Gene Variations are Associated with Coronary Artery Disease.” | 0.98 | hgnc_dict_v1 |
| gene | TCF7L2 | “Dysregulated Vitamin D, CYP2R1, TCF7L2, and CCR5 Δ32 Gene Variations are Associated with Coronary Artery Disease.” | 0.98 | hgnc_dict_v1 |
Physical exercise reduces the expression of RANTES and its CCR5 receptor in the adipose tissue of obese humans.
PMID 24895488 | PMCID PMC4016945 | DOI 10.1155/2014/627150 · Mediators of inflammation · 2014 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CCR5 | “Physical exercise reduces the expression of RANTES and its CCR5 receptor in the adipose tissue of obese humans.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “Therefore, physical exercise may provide an effective approach for combating the deleterious effects associated with obesity through RANTES signaling in the adipose tissue.” | 0.98 | phenotype_alias_lexicon_v2 |