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CD36 and leukemia are reported together in 2 articles.
Gene
CD36
- HGNC
- HGNC:1663
23articles
23mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
dyslipidemia 4diabetes mellitus 3leukemia 2obesity 2Alzheimer disease 1breast cancer 1lung cancer 1metabolic syndrome 1
Reported variants (articles · ClinVar status)
Phenotype
Leukemia
652articles
652mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche.
PMID 38316788 | PMCID PMC10844594 | DOI 10.1038/s41467-024-45471-0 · Nature communications · 2024 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD36 | “CML exposed macrophages separate from their normal counterparts by reduced expression of the surface marker CD36, which significantly reduces clearance of apoptotic cells.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | ABL1 | “Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche.” | 0.98 | hgnc_dict_v1 |
| gene | LTF | “We uncover aberrant production of CML-secreted factors, including the immune modulatory protein lactotransferrin (LTF), that suppresses efferocytosis, phagocytosis, and CD36 surface expression in BM macrophages, indicating that the elevated secretion of LTF is, at least partially responsible for the supressed clearance function of Ph- macrophages.” | 0.98 | hgnc_dict_v1 |
Fatty acids secreted from head and neck cancer induce M2-like Macrophages.
PMID 35213745 | DOI 10.1002/JLB.1A0521-251R · Journal of leukocyte biology · 2022 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD36 | “Macrophages were examined for markers of maturation (CD14, CD68), activation (HLA-DR, CD86, IL15R), scavenger receptor (CD36), toll-like receptor (TLR4), M2 marker (CD206), immune checkpoint (PD-L1), and intracellular chemokine expression (IP-10).” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “Purified monocytes were incubated in medium or medium supplemented with supernatants from FaDu and SCC9 or the leukemia monocytic cell line, THP-1.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CD14 | “Macrophages were examined for markers of maturation (CD14, CD68), activation (HLA-DR, CD86, IL15R), scavenger receptor (CD36), toll-like receptor (TLR4), M2 marker (CD206), immune checkpoint (PD-L1), and intracellular chemokine expression (IP-10).” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “Macrophages were examined for markers of maturation (CD14, CD68), activation (HLA-DR, CD86, IL15R), scavenger receptor (CD36), toll-like receptor (TLR4), M2 marker (CD206), immune checkpoint (PD-L1), and intracellular chemokine expression (IP-10).” | 0.98 | hgnc_dict_v1 |