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CD4 and diabetes mellitus are reported together in 3 articles.
Gene
CD4
- HGNC
- HGNC:1678
84articles
84mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Diabetes mellitus
2,156articles
2,156mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Identification of cell specific biomarkers for intellectual disability via single cell RNA sequencing and transcriptomic bioinformatics approaches.
PMID 40399537 | PMCID PMC12095737 | DOI 10.1038/s41598-025-85162-4 · Scientific reports · 2025 · 13 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD4 | “Specific genetic disorders that result in ID can also have immune system anomalies, such as changes in T (CD4+ and CD8+) cell activity.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Furthermore, the DAVID online platform and FunRich software were utilized to detect signal transduction and translation, immune response, MHC (Major Histocompatibility Complex) class II, antigen processing and presentation, allograft rejection and important pathways of type I diabetes mellitus.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | RPS27A | “In this investigation, six ribosomal proteins (RPS27A, RPS21, RPS18, RPS7, RPS5, and RPL9) have been identified as the hub genes of ID from PPI.” | 0.98 | hgnc_dict_v1 |
| gene | RPS21 | “In this investigation, six ribosomal proteins (RPS27A, RPS21, RPS18, RPS7, RPS5, and RPL9) have been identified as the hub genes of ID from PPI.” | 0.98 | hgnc_dict_v1 |
Phenotypical evaluation of lymphocytes and monocytes in patients with type 2 diabetes mellitus in Saudi Arabia.
PMID 36940958 | PMCID PMC10043885 | DOI 10.15537/smj.2023.44.3.20220873 · Saudi medical journal · 2023 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD4 | “In addition, patients with T2DM showed lower percentage of total T-lymphocytes (CD3+) and CD4 T-cells, but higher CD8 T-cell expression.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Phenotypical evaluation of lymphocytes and monocytes in patients with type 2 diabetes mellitus in Saudi Arabia.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CD19 | “OBJECTIVES: To evaluate the levels of total lymphocytes, B-lymphocytes (CD19+), T-lymphocytes (CD3+), natural killer (NK) cells (CD3-/CD56+), and monocyte subsets in type 2 diabetes mellitus (T2DM) patients in Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| population | Saudi Arabia | “Phenotypical evaluation of lymphocytes and monocytes in patients with type 2 diabetes mellitus in Saudi Arabia. OBJECTIVES: To evaluate the levels of total lymphocytes, B-lymphocytes (CD19+), T-lymphocytes (CD3+), natural killer (NK) cells (CD3-/CD56+), and monocyte subsets in type 2 diabetes mellitus (T2DM) patients in Saudi Arabia. METHODS: A case-control study included 95 participants recruited in the study: 62 patients with T2DM and 33 healthy individuals. All the patients were admitted to the Diabetic Centre in Taif, Saudi Arabia.” | 0.95 | saudi_context_rules_v1 |
Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.
PMID 34127860 | PMCID PMC8273124 | DOI 10.1038/s41588-021-00880-5 · Nature genetics · 2021 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD4 | “We define credible sets of T1D-associated variants and show that they are enriched in immune-cell accessible chromatin, particularly CD4+ effector T cells.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | BACH2 | “We highlight rs72928038 in BACH2 as a candidate causal T1D variant leading to decreased enhancer accessibility and BACH2 expression in T cells.” | 0.98 | hgnc_dict_v1 |
| variant | rs72928038 | “We highlight rs72928038 in BACH2 as a candidate causal T1D variant leading to decreased enhancer accessibility and BACH2 expression in T cells.” | 0.90 | hgvs_regex_v1 |