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CD4 and leukemia are reported together in 6 articles.
Gene
CD4
- HGNC
- HGNC:1678
84articles
84mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Leukemia
652articles
652mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
6 records shown · first 60The significance of galectin-9 and T-cell immunoglobulin and mucin domain-containing molecule-3 (TIM-3) in patients with chronic lymphocytic leukemia: The role of immune evasion.
PMID 42391833 | DOI 10.1016/j.humimm.2026.111786 · Human immunology · 2026 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD4 | “Gal-9 expression was estimated by real-time polymerase chain reaction, while flow cytometric %TIM-3+ on CD3+, CD3+CD4+, and CD3+CD8+ T cells was measured.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “The significance of galectin-9 and T-cell immunoglobulin and mucin domain-containing molecule-3 (TIM-3) in patients with chronic lymphocytic leukemia: The role of immune evasion.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CD38 | “Additionally, they had significant correlations with prognostic markers, including β2-microglobulin, LDH, chromosomal abnormalities, CD38, and Rai stage.” | 0.98 | hgnc_dict_v1 |
First case of primary CNS lymphoma in a patient with severe combined immunodeficiency carrying a novel ZAP70 mutation: a case report.
PMID 40901120 | PMCID PMC12401455 | DOI 10.1097/MS9.0000000000003591 · Annals of medicine and surgery (2012) · 2025 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD4 | “Immunological workup at 18 years of age showed CD4+ and CD8+ T-cell lymphopenia, and genetic analysis revealed a homozygous pathogenic ZAP70 splice-site mutation (c.402 + 2 T>C).” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “ZAP70 deficiency is typically associated with combined immunodeficiency and rarely with malignancies such as leukemia or lymphoma.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | ZAP70 | “First case of primary CNS lymphoma in a patient with severe combined immunodeficiency carrying a novel ZAP70 mutation: a case report.” | 0.98 | hgnc_dict_v1 |
| phenotype | lymphoma | “First case of primary CNS lymphoma in a patient with severe combined immunodeficiency carrying a novel ZAP70 mutation: a case report.” | 0.98 | phenotype_alias_lexicon_v2 |
Herpesvirus Entry Mediator as an Immune Checkpoint Target and a Potential Prognostic Biomarker in Myeloid and Lymphoid Leukemia.
PMID 38785930 | PMCID PMC11117912 | DOI 10.3390/biom14050523 · Biomolecules · 2024 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD4 | “This study aims to determine whether HVEM is an immune checkpoint target with inhibitory effects on anti-tumor CD4+ T cell responses in vitro and whether HVEM gene expression is dysregulated in patients with acute lymphocytic leukemia (ALL).” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “Herpesvirus Entry Mediator as an Immune Checkpoint Target and a Potential Prognostic Biomarker in Myeloid and Lymphoid Leukemia.” | 0.98 | phenotype_alias_lexicon_v2 |
Effects of plant-derived anti-leukemic drugs on individualized leukemic cell population profiles in Egyptian patients.
PMID 26870259 | PMCID PMC4727189 | DOI 10.3892/ol.2015.3916 · Oncology letters · 2016 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD4 | “An increased expression of LAIPs, including CD4, CD14, CD33 and CD34, was considered a surrogate marker of the desired response of leukemia cells to treatment with plant-derived drugs.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “The relationship between treatments with plant-derived drugs and leukemia-associated immunophenotypes (LAIPs) of clinically isolated leukemia cells has yet to be established.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CD14 | “An increased expression of LAIPs, including CD4, CD14, CD33 and CD34, was considered a surrogate marker of the desired response of leukemia cells to treatment with plant-derived drugs.” | 0.98 | hgnc_dict_v1 |
| gene | CD33 | “An increased expression of LAIPs, including CD4, CD14, CD33 and CD34, was considered a surrogate marker of the desired response of leukemia cells to treatment with plant-derived drugs.” | 0.98 | hgnc_dict_v1 |
Simultaneous existence of acute myeloid leukemia and chronic lymphocytic leukemia: a case report.
PMID 27643996 | PMCID PMC5028963 | DOI 10.1186/s12885-016-2780-5 · BMC cancer · 2016 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD4 | “The immunologic phenotype of blasts was characterized by the co-expression of CD13, CD33, CD14, CD4, CD15, CD64, HLA-DR, CD11c.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “Simultaneous existence of acute myeloid leukemia and chronic lymphocytic leukemia: a case report.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CD33 | “The immunologic phenotype of blasts was characterized by the co-expression of CD13, CD33, CD14, CD4, CD15, CD64, HLA-DR, CD11c.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “The immunologic phenotype of blasts was characterized by the co-expression of CD13, CD33, CD14, CD4, CD15, CD64, HLA-DR, CD11c.” | 0.98 | hgnc_dict_v1 |
Immunophenotyping of peripheral blood lymphocytes in Saudi men.
PMID 11874863 | PMCID PMC119953 | DOI 10.1128/cdli.9.2.279-281.2002 · Clinical and diagnostic laboratory immunology · 2002 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD4 | “We investigated the expression of T-cell markers (CD3, CD4, and CD8), B cells (CD19), and natural killer cells (CD16 and CD56).” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “Flow cytometry is an important tool for the diagnosis and follow-up of immunodeficiency patients, as well as for patients with leukemia and lymphoma.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CD19 | “We investigated the expression of T-cell markers (CD3, CD4, and CD8), B cells (CD19), and natural killer cells (CD16 and CD56).” | 0.98 | hgnc_dict_v1 |
| phenotype | lymphoma | “Flow cytometry is an important tool for the diagnosis and follow-up of immunodeficiency patients, as well as for patients with leukemia and lymphoma.” | 0.98 | phenotype_alias_lexicon_v2 |