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CD4 and multiple sclerosis are reported together in 5 articles.
Gene
CD4
- HGNC
- HGNC:1678
84articles
84mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Multiple sclerosis
236articles
236mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
5 records shown · first 60Probiotic-Fermented Camel Milk Attenuates Neurodegenerative Symptoms via SOX5/miR-218 Axis Orchestration in Mouse Models.
PMID 36986457 | PMCID PMC10059028 | DOI 10.3390/ph16030357 · Pharmaceuticals (Basel, Switzerland) · 2023 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD4 | “It has been demonstrated that several genetic and epigenetic factors control autoimmune encephalomyelitis (EAE), a murine model of MS, through CD4+ T-cell population quantity.” | 0.98 | hgnc_dict_v1 |
| phenotype | multiple sclerosis | “Multiple sclerosis is an autoimmune-mediated myelin damage disorder in the central nervous system that is widespread among neurological patients.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | SOX5 | “Probiotic-Fermented Camel Milk Attenuates Neurodegenerative Symptoms via SOX5/miR-218 Axis Orchestration in Mouse Models.” | 0.98 | hgnc_dict_v1 |
CCR1 antagonist J-113863 corrects the imbalance of pro- and anti-inflammatory cytokines in a SJL/J mouse model of relapsing-remitting multiple sclerosis.
PMID 35868215 | DOI 10.1016/j.imbio.2022.152245 · Immunobiology · 2022 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD4 | “We investigated the effect of J-113863 on expression levels of GM-CSF, IL-6, IL-10, IL-27 in CD4+ spleen cells, using flow cytometry.” | 0.98 | hgnc_dict_v1 |
| phenotype | multiple sclerosis | “CCR1 antagonist J-113863 corrects the imbalance of pro- and anti-inflammatory cytokines in a SJL/J mouse model of relapsing-remitting multiple sclerosis.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CCR1 | “CCR1 antagonist J-113863 corrects the imbalance of pro- and anti-inflammatory cytokines in a SJL/J mouse model of relapsing-remitting multiple sclerosis.” | 0.98 | hgnc_dict_v1 |
RNA-sequencing and mass-spectrometry proteomic time-series analysis of T-cell differentiation identified multiple splice variants models that predicted validated protein biomarkers in inflammatory diseases.
PMID 36106020 | PMCID PMC9465313 | DOI 10.3389/fmolb.2022.916128 · Frontiers in molecular biosciences · 2022 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD4 | “We characterised time-series of primary human naïve CD4+ T cells during early T helper type 1 differentiation with RNA-sequencing and mass-spectrometry proteomics.” | 0.98 | hgnc_dict_v1 |
| phenotype | multiple sclerosis | “Lastly, we re-analysed RNA-seq datasets to evaluate biomarker discovery in five T-cell associated diseases, further validating the findings for multiple sclerosis (MS) and asthma.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | asthma | “Lastly, we re-analysed RNA-seq datasets to evaluate biomarker discovery in five T-cell associated diseases, further validating the findings for multiple sclerosis (MS) and asthma.” | 0.98 | phenotype_alias_lexicon_v2 |
Deep characterization of paired chromatin and transcriptomes in four immune cell types from multiple sclerosis patients.
PMID 34676774 | DOI 10.2217/epi-2021-0205 · Epigenomics · 2021 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD4 | “Material & methods: We generated paired assay for transposase-accessible chromatin sequencing and RNA-sequencing profiles from sorted blood immune CD4+ and CD8+ T cells, CD14+ monocytes and CD19+ B cells from healthy controls (HCs) and MS patients.” | 0.98 | hgnc_dict_v1 |
| phenotype | multiple sclerosis | “Deep characterization of paired chromatin and transcriptomes in four immune cell types from multiple sclerosis patients.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CD14 | “Material & methods: We generated paired assay for transposase-accessible chromatin sequencing and RNA-sequencing profiles from sorted blood immune CD4+ and CD8+ T cells, CD14+ monocytes and CD19+ B cells from healthy controls (HCs) and MS patients.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “Material & methods: We generated paired assay for transposase-accessible chromatin sequencing and RNA-sequencing profiles from sorted blood immune CD4+ and CD8+ T cells, CD14+ monocytes and CD19+ B cells from healthy controls (HCs) and MS patients.” | 0.98 | hgnc_dict_v1 |
Hypermethylation of MIR21 in CD4+ T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes.
PMID 28766461 | PMCID PMC5794671 | DOI 10.1177/1352458517721356 · Multiple sclerosis (Houndmills, Basingstoke, England) · 2018 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD4 | “Hypermethylation of MIR21 in CD4+ T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes.” | 0.98 | hgnc_dict_v1 |
| phenotype | multiple sclerosis | “Hypermethylation of MIR21 in CD4+ T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | MIR21 | “Hypermethylation of MIR21 in CD4+ T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes.” | 0.98 | hgnc_dict_v1 |
| gene | VMP1 | “RESULTS: We observed significant methylation differences in the VMP1/MIR21 locus, with RR-MS displaying higher methylation compared to SP-MS and HC.” | 0.98 | hgnc_dict_v1 |