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CD4 and systemic lupus erythematosus are reported together in 3 articles.
Gene
CD4
- HGNC
- HGNC:1678
84articles
84mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Systemic lupus erythematosus
191articles
191mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60The PPAR-α selective agonist WY14643 improves lupus nephritis via the downregulation of the RORγT/STAT3 signaling pathway in MRL/lpr mice.
PMID 39653614 | DOI 10.1016/j.intimp.2024.113787 · International immunopharmacology · 2025 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD4 | “Flow cytometry was used to examinethe effects of WY14643 on the expression of IL-17A, STAT3, RORγT, IL-21, IL-21R, IL-22, and TNF-α in splenic CD4+ T cells.” | 0.98 | hgnc_dict_v1 |
| phenotype | systemic lupus erythematosus | “The PPAR-α selective agonist WY14643 improves lupus nephritis via the downregulation of the RORγT/STAT3 signaling pathway in MRL/lpr mice.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | STAT3 | “The PPAR-α selective agonist WY14643 improves lupus nephritis via the downregulation of the RORγT/STAT3 signaling pathway in MRL/lpr mice.” | 0.98 | hgnc_dict_v1 |
Analysis of CD95 and CCR7 expression on circulating CD4(+) lymphocytes revealed disparate immunoregulatory potentials in systemic lupus erythematosus.
PMID 26858545 | PMCID PMC4705260 | DOI 10.1016/j.sjbs.2015.05.003 · Saudi journal of biological sciences · 2016 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD4 | “Analysis of CD95 and CCR7 expression on circulating CD4(+) lymphocytes revealed disparate immunoregulatory potentials in systemic lupus erythematosus.” | 0.98 | hgnc_dict_v1 |
| phenotype | systemic lupus erythematosus | “Analysis of CD95 and CCR7 expression on circulating CD4(+) lymphocytes revealed disparate immunoregulatory potentials in systemic lupus erythematosus.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CCR7 | “Analysis of CD95 and CCR7 expression on circulating CD4(+) lymphocytes revealed disparate immunoregulatory potentials in systemic lupus erythematosus.” | 0.98 | hgnc_dict_v1 |
Superantigen influence in conjunction with cytokine polymorphism potentiates autoimmunity in systemic lupus erythematosus patients.
PMID 26676360 | DOI 10.1007/s12026-015-8768-4 · Immunologic research · 2016 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD4 | “Using streptococcal pyrogenic exotoxin A and staphylococcal enterotoxin B as prototype superantigens, we have demonstrated that they profoundly affect the magnitude of polyclonal T cell response, particularly CD4(+) T cells and expression of CD45RA and CD45RO, and cytokine secretion in vitro in SLE patient PBMCs.” | 0.98 | hgnc_dict_v1 |
| phenotype | systemic lupus erythematosus | “Superantigen influence in conjunction with cytokine polymorphism potentiates autoimmunity in systemic lupus erythematosus patients.” | 0.98 | phenotype_alias_lexicon_v2 |