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CD40 and neurodevelopmental disorder are reported together in 3 articles.
Gene
CD40
- HGNC
- HGNC:11919
24articles
24mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
autism spectrum disorder 4neurodevelopmental disorder 3rheumatoid arthritis 3leukemia 2pre-eclampsia 2recurrent pregnancy loss 2Down syndrome 1Klinefelter syndrome 1
Reported variants (articles · ClinVar status)
Phenotype
Neurodevelopmental disorder
- HPO
- HP:0012759
450articles
450mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60A potent and selective CXCR2 antagonist improves neuroimmune dysregulation through the inhibition of NF-κB and notch inflammatory signaling in the BTBR mouse model of autism.
PMID 36931207 | DOI 10.1016/j.jneuroim.2023.578069 · Journal of neuroimmunology · 2023 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD40 | “In this study, we investigated the effects of SB332235 administration on NF-κB-, Notch-1-, Notch-3-, GM-CSF-, MCP-1-, IL-6-, and IL-2- and TGF-β1-expressing CD40+ cells in BTBR and C57BL/6 (C57) mice in the spleen cells by flow cytometry.” | 0.98 | hgnc_dict_v1 |
| phenotype | neurodevelopmental disorder | “Autism comprises a broad range of neurodevelopmental disorders characterized by social communication deficits and repetitive and stereotyped behaviors.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CXCR2 | “A potent and selective CXCR2 antagonist improves neuroimmune dysregulation through the inhibition of NF-κB and notch inflammatory signaling in the BTBR mouse model of autism.” | 0.98 | hgnc_dict_v1 |
| phenotype | autism spectrum disorder | “A potent and selective CXCR2 antagonist improves neuroimmune dysregulation through the inhibition of NF-κB and notch inflammatory signaling in the BTBR mouse model of autism.” | 0.93 | phenotype_alias_lexicon_v2 |
Upregulation of Inflammatory Mediators in Peripheral Blood CD40+ Cells in Children with Autism Spectrum Disorder.
PMID 37108638 | PMCID PMC10138695 | DOI 10.3390/ijms24087475 · International journal of molecular sciences · 2023 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD40 | “Upregulation of Inflammatory Mediators in Peripheral Blood CD40+ Cells in Children with Autism Spectrum Disorder.” | 0.98 | hgnc_dict_v1 |
| phenotype | neurodevelopmental disorder | “Autism spectrum disorder (ASD) is a common and severe neurodevelopmental disorder in early childhood, defined as social and communication deficits and repetitive and stereotypic behaviours.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CCR1 | “C-C chemokine receptor type 1 (CCR1) activation is pro-inflammatory in several neurological disorders.” | 0.98 | hgnc_dict_v1 |
| phenotype | autism spectrum disorder | “Upregulation of Inflammatory Mediators in Peripheral Blood CD40+ Cells in Children with Autism Spectrum Disorder.” | 0.98 | phenotype_alias_lexicon_v2 |
Methylmercury chloride exposure aggravates proinflammatory mediators and Notch-1 signaling in CD14+ and CD40+ cells and is associated with imbalance of neuroimmune function in BTBR T+ Itpr3tf/J mice.
PMID 33166615 | DOI 10.1016/j.neuro.2020.10.014 · Neurotoxicology · 2021 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD40 | “Methylmercury chloride exposure aggravates proinflammatory mediators and Notch-1 signaling in CD14+ and CD40+ cells and is associated with imbalance of neuroimmune function in BTBR T+ Itpr3tf/J mice.” | 0.98 | hgnc_dict_v1 |
| phenotype | neurodevelopmental disorder | “Autism spectrum disorder (ASD) is a severe neurodevelopmental disorder characterized by deficits in social interaction, communication, and repetitive behaviors.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CD14 | “Methylmercury chloride exposure aggravates proinflammatory mediators and Notch-1 signaling in CD14+ and CD40+ cells and is associated with imbalance of neuroimmune function in BTBR T+ Itpr3tf/J mice.” | 0.98 | hgnc_dict_v1 |
| phenotype | autism spectrum disorder | “Autism spectrum disorder (ASD) is a severe neurodevelopmental disorder characterized by deficits in social interaction, communication, and repetitive behaviors.” | 0.98 | phenotype_alias_lexicon_v2 |