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CD44 and lung cancer are reported together in 4 articles.
Gene
CD44
- HGNC
- HGNC:1681
74articles
74mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 14colorectal cancer 7lung cancer 4diabetes mellitus 3ovarian cancer 3epilepsy 2hepatocellular carcinoma 2inflammatory bowel disease 2
Reported variants (articles · ClinVar status)
Phenotype
Lung cancer
398articles
398mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
4 records shown · first 60Decoding Prognostic Signatures in Brain Metastatic Non-Small-Cell Lung Cancer via Integrated Multi-Omics and Network Analysis.
PMID 42074236 | PMCID PMC13116879 | DOI 10.3390/ijms27083598 · International journal of molecular sciences · 2026 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD44 | “We finally constructed a three-node microRNA (miRNA) feed-forward loop (FFL) involving miR-23b-3p, CD44, and five transcription factors (TFs) [EOMES, FOS, FOSL1, GLIS3, TP63] specific to NSCLC metastasis.” | 0.98 | hgnc_dict_v1 |
| phenotype | lung cancer | “Decoding Prognostic Signatures in Brain Metastatic Non-Small-Cell Lung Cancer via Integrated Multi-Omics and Network Analysis.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | EOMES | “We finally constructed a three-node microRNA (miRNA) feed-forward loop (FFL) involving miR-23b-3p, CD44, and five transcription factors (TFs) [EOMES, FOS, FOSL1, GLIS3, TP63] specific to NSCLC metastasis.” | 0.98 | hgnc_dict_v1 |
| gene | FOSL1 | “We finally constructed a three-node microRNA (miRNA) feed-forward loop (FFL) involving miR-23b-3p, CD44, and five transcription factors (TFs) [EOMES, FOS, FOSL1, GLIS3, TP63] specific to NSCLC metastasis.” | 0.98 | hgnc_dict_v1 |
Potential Role of Tumor-derived MIF in B-Cell Antigen Presentation in Lung Adenocarcinoma: Single-cell and TCGA Analyses.
PMID 41318120 | DOI 10.21873/anticanres.17874 · Anticancer research · 2025 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD44 | “RESULTS: Malignant cells showed the highest expression of MIF, which may interact with CD74 + CXCR4 + and CD74 + CD44 + receptor complexes on B cells, T cells, and myeloid cells, consistent with known MIF-mediated signaling pathways.” | 0.98 | hgnc_dict_v1 |
| phenotype | lung cancer | “BACKGROUND/AIM: Lung adenocarcinoma (LUAD), a predominant subtype of non-small cell lung cancer (NSCLC), is characterized by a complex tumor microenvironment (TME) that drives immune evasion and contributes to variable clinical outcomes.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CD74 | “RESULTS: Malignant cells showed the highest expression of MIF, which may interact with CD74 + CXCR4 + and CD74 + CD44 + receptor complexes on B cells, T cells, and myeloid cells, consistent with known MIF-mediated signaling pathways.” | 0.98 | hgnc_dict_v1 |
| gene | CXCR4 | “RESULTS: Malignant cells showed the highest expression of MIF, which may interact with CD74 + CXCR4 + and CD74 + CD44 + receptor complexes on B cells, T cells, and myeloid cells, consistent with known MIF-mediated signaling pathways.” | 0.98 | hgnc_dict_v1 |
Absence of CD74 Isoform at 41kDa Prevents the Heterotypic Associations between CD74 and CD44 in Human Lung Adenocarcinoma-derived Cells.
PMID 32646312 | DOI 10.1080/08820139.2020.1790594 · Immunological investigations · 2021 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD44 | “Absence of CD74 Isoform at 41kDa Prevents the Heterotypic Associations between CD74 and CD44 in Human Lung Adenocarcinoma-derived Cells.” | 0.98 | hgnc_dict_v1 |
| phenotype | lung cancer | “Lung cancer is a leading cause of cancer-associated death in all over the globe.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CD74 | “Absence of CD74 Isoform at 41kDa Prevents the Heterotypic Associations between CD74 and CD44 in Human Lung Adenocarcinoma-derived Cells.” | 0.98 | hgnc_dict_v1 |
Blood classical monocytes phenotype is not altered in primary non-small cell lung cancer.
PMID 25493244 | PMCID PMC4259935 | DOI 10.5306/wjco.v5.i5.1078 · World journal of clinical oncology · 2014 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD44 | “Expression of CD11b, CD11c, CD71 and CD44 was also shown to be similar in patients with NSCLC compared to non-cancer controls.” | 0.98 | hgnc_dict_v1 |
| phenotype | lung cancer | “Blood classical monocytes phenotype is not altered in primary non-small cell lung cancer.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CD14 | “Flow cytometry was performed to investigate M1 and M2 phenotypes in peripheral monocytes (classical monocytes CD14+, CD45+ and CD16-) using conventional surface markers.” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “RESULTS: There were no significant difference in expression of M1 (HLA-DR) and/or M2 markers (CD163 and CD36) markers on classical monocytes in patients with NSCLC compared to non-cancer controls.” | 0.98 | hgnc_dict_v1 |