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CD59 and breast cancer are reported together in 1 article.
Gene
CD59
- HGNC
- HGNC:1689
4articles
4mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Breast cancer
1,211articles
1,211mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Therapy-induced senescent cancer cells exhibit complement activation and increased complement regulatory protein expression.
PMID 38265162 | DOI 10.1111/imcb.12727 · Immunology and cell biology · 2024 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD59 | “In cell lines undergoing TIS, complement-related changes included (i) activation of the terminal pathway, evidenced by the deposition of C5b-9 on senescent cells; (ii) an increase in the expression of CD59 and complement factor H and (iii) in A549 cells, an elevation in the expression of C3 with its secretion into the medium.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “In addition, increased C3 expression was observed in breast cancer samples expressing TIS hallmarks following exposure to neoadjuvant chemotherapy.” | 0.98 | phenotype_alias_lexicon_v2 |